Browsing by Author "Bakir, Mehmet"
Now showing items 21-31 of 31
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A new perspective to determine the severity of cases with Crimean-Congo hemorrhagic fever
Bakir, Mehmet; Engin, Aynur; Gozel, Mustafa Gokhan; Elaldi, Nazif; Kilickap, Saadettin; Cinar, Ziynet (MALARIA RESEARCH CENTRE, INDIAN COUNCIL MEDICAL RESEARCH-ICMR, 2012)Background & objectives: We have established a severity grading score (SOS) system for predicting the fatality :in Crimean-Congo hemorrhagic fever (CCHF) for the first time. Methods: This SOS has been set up by using several ... -
Ocular Findings in Patients with Crimean-Congo Hemorrhagic Fever
Engin, Aynur; Erdogan, Haydar; Ozec, Ayse Vural; Elaldi, Nazif; Toker, Mustafa Ilker; Bakir, Mehmet; Dokmetas, Ilyas; Arici, Mustafa Kemal (ELSEVIER SCIENCE INC, 2009)PURPOSE: To describe ocular findings of patients with Crimean-Congo hemorrhagic fever (CCHF). DESIGN: Prospective, interventional, consecutive case series. METHODS: This study was conducted in Sivas, a city located in the ... -
Presepsin Levels of Patients with Crimean-Congo Hemorrhagic Fever
Demirpence, Ozlem; Dogan, Halef Okan; Ersan, Serpil; Sahin, Mehtap; Sahin, Hasan; Bakir, Mehmet (NATL INST INFECTIOUS DISEASES, 2016)Levels of presepsin (a soluble cluster of differentiation subtype 14 [CD14]) are thought to increase in cases of bacterial infection. CD14 has also been found to play a role in the pathogenesis of various viral diseases. ... -
The protective effect and diagnostic performance of NOX-5 in Crimean-Congo haemorrhagic fever patients
Buyuktuna, Seyit Ali; Dogan, Halef Okan; Bakir, Mehmet; Elaldi, Nazif; Gozel, Mustafa Gokhan; Engin, Aynur (MICROBIOLOGY SOC, 2018)Introduction. Crimean-Congo haemorrhagic fever (CCHF) is an acute viral haemorrhagic disease. Reactive oxygen species that are mainly generated by the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) enzyme ... -
Recommended precaution procedures protect healthcare workers from Crimean-Congo hemorrhagic fever virus
Gozel, Mustafa Gokhan; Dokmetas, Ilyas; Oztop, Atifet Yasemin; Engin, Aynur; Elaldi, Nazif; Bakir, Mehmet (ELSEVIER SCI LTD, 2013)Objectives: The Crimean-Congo hemorrhagic fever (CCHF) virus can spread from person to person and may cause nosocomial outbreaks among healthcare workers (HCWs). The US Centers for Disease Control and Prevention have ... -
Relationship between IFNA1, IFNA5, IFNA10, and IFNA17 gene polymorphisms and Crimean-Congo hemorrhagic fever prognosis in a Turkish population range
Elaldi, Nazif; Yilmaz, Meral; Bagci, Binnur; Yelkovan, Izzet; Bagci, Gokhan; Gozel, Mustafa Gokhan; Engin, Aynur; Bakir, Mehmet; Dokmetas, Ilyas (WILEY, 2016)Crimean-Congo hemorrhagic fever (CCHF) is a fatal emerging acute viral infection. Not much is known regarding the pathogenic mechanisms and the reasons behind severe or mild disease courses in CCHF. IFN-alpha (IFNA) is one ... -
Relationship of plasma cell-free DNA level with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever
Bakir, Mehmet; Engin, Aynur; Kuskucu, Mert Ahmet; Bakir, Sevtap; Gundag, Omur; Midilli, Kenan (WILEY, 2016)Crimean-Congo hemorrhagic fever (CCHF) is a viral infection. Circulating plasma cell-free DNA (pcf-DNA) is a novel marker indicating cellular damage. So far, the role of pcf-DNA did not investigate in CCHF patients. In the ... -
Sequential determination of serum viral titers, virus-specific IgG antibodies, and TNF-alpha, IL-6, IL-10, and IFN-gamma levels in patients with Crimean-Congo hemorrhagic fever
Kaya, Safak; Elaldi, Nazif; Kubar, Ayhan; Gursoy, Nevcihan; Yilmaz, Meral; Karakus, Gulderen; Gunes, Turabi; Polat, Zubeyde; Gozel, Mustafa Gokhan; Engin, Aynur; Dokmetas, Ilyas; Bakir, Mehmet; Yilmaz, Neziha; Sencan, Mehmet (BIOMED CENTRAL LTD, 2014)Background: Although there have been a number of studies on the pathogenesis of Crimean-Congo hemorrhagic fever (CCHF) recently, knowledge on this topic is still insufficient. This study aims to reveal the kinetics of serum ... -
Serum Levels of Mannan-Binding Lectin in Patients with Crimean-Congo Hemorrhagic Fever
Engin, Aynur; Ugurlu, Serdal; Caglar, Erkan; Oztop, Atifet Yasemin; Inan, Dursun; Elaldi, Nazif; Dokmetas, Ilyas; Bakir, Mehmet (MARY ANN LIEBERT, INC, 2010)Objective: Mannan-binding lectin (MBL) is a central component of the innate immune response. Genetic variations in the MBL gene that reduce circulating levels and alter functional properties of the MBL are associated with ... -
Toll-like Receptor 7 Gln11Leu, c.4-151A/G, and+1817G/T Polymorphisms in Crimean Congo Hemorrhagic Fever
Arslan, Serdal; Engin, Aynur; Ozbilum, Nil; Bakir, Mehmet (WILEY, 2015)Crimean-Congo hemorrhagic fever (CCHF) is a viral zoonosis. Toll-like receptors (TLRs) initiate signaling cascades leading to the activation of the innate immune system following CCHF infection. In this study, TLR7 (Gln11Leu, ... -
Toll-like receptor 8 and 9 polymorphisms in Crimean-Congo hemorrhagic fever
Engin, Aynur; Arslan, Serdal; Kizildag, Sibel; Ozturk, Hasret; Elaldi, Nazif; Dokmetas, Ilyas; Bakir, Mehmet (ELSEVIER SCIENCE BV, 2010)Crimean-Congo hemorrhagic fever (CCHF) is an acute viral hemorrhagic fever The clinical course and outcome of the CCHF infection are different in humans Toll like receptors (TLRs) are a family of pathogen recognition ...