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Structurally diverse heterobimetallic Pb(II)-Salen complexes mechanistic notion of cytotoxic activity against neuroblastoma cancer cell: Synthesis, characterization, protein–ligand interaction profiler, and intuitions from DFT
(24 Septemb)
In this work, two new heterobimetallic Pb(II) complexes, namely [Zn(L1)(η1-NCS)Pb(η1-SCN)] (1) and [Cd(L2)
(η1-NCS)Pb(η1-SCN)]n (2) integrated from Salen ligands (L1/L2) in the presence of NaSCN. The title compounds
were ...
Investigation of structural, electronical and in vitro cytotoxic activity properties of some heterocyclic compounds
(19 July 20)
A series of heterocyclic compounds ( 15 ) were synthesized, characterized and tested towards two human cancer cell lines for learning their in vitro antiproliferative activities. Compound 3 demonstrated the most promising ...
Could Peganum harmala be effective in the treatment of COVID-19?
(2021)
BACKGROUND: Predominant molecules in Peganum harmala leaves were detected using gas
chromatography-mass spectrometry (GC-MS). Based on the results of this analysis, most alkaloids,
fl avonoids and triterpenoids in found ...
Are clarithromycin, azithromycin and their analogues effective in the treatment of COVID19?
(2021)
BACKGROUND: SARS-CoV-2, which started in Wuhan and later affected the whole world, is the most
important disease of the world today. Many ways to inhibit SARS-CoV-2 virus are sought to prevent the
spread of this virus. ...
Could boron-containing compounds (BCCs) be effective against SARS-CoV-2 as anti-viral agent?
(2021)
BACKGROUND: Seven dioxaborole compounds are investigated in this study. Structural and spectral
characterizations are done at the M062X/6-31+G(d,p) level in water. Active sites of these compounds are
determined by contour ...
Synthesis of (4R)-2-(3-hydroxyphenyl)thiazolidine- 4-carboxylic acid substituted phthalocyanines: Anticancer activity on different cancer cell lines and molecular docking studies
(9 March 20)
In this study, firstly, (4R)-2-(3-hydroxyphenyl)thiazolidine-4-carboxylic acid (1)
and (4R)-2-(3-(3,4-dicyanophenoxy)phenyl)thiazolidine-4-carboxylic acid (2)
were prepared. Then, the novel type metallophthalocyanines ...
Could Peganum harmala be effective in the treatment of COVID-19?
(2021)
BACKGROUND: Predominant molecules in Peganum harmala leaves were detected using gas
chromatography-mass spectrometry (GC-MS). Based on the results of this analysis, most alkaloids,
fl avonoids and triterpenoids in found ...
Determination of inhibitor activity of drugs against the COVID-19
(2021)
BACKGROUND: It is the SARS-CoV-2 virus, one of the most signifi cant diseases of today’s world. Due to the
high transmission of this disease, studies are ongoing to discover an inhibitor drug that can stop this disease.
In ...
Synthesis, molecular docking, and biological activities of new cyanopyridine derivatives containing phenylurea
(2021)
A new class of cyanopyridine derivatives (10a-e and 11a-e) containing the phenylurea unit was synthesized and tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and ...
Cytotoxic effect, spectroscopy, DFT, enzyme inhibition, and moleculer docking studies of some novel mesitylaminopropanols: Antidiabetic and anticholinergics and anticancer potentials
(09 October)
b-Amino alcohols (2–4) used in this study were re-synthesized in accordance with our previous study. All
compounds were characterized by the combination of NMR, UV–Vis, IR experimental and theoretical
spectral data. Then, ...
