dc.contributor.author | Gunes, Emine Gulsen | |
dc.contributor.author | Pinarbasi, Ergun | |
dc.contributor.author | Pinarbasi, Hatice | |
dc.contributor.author | Silig, Yavuz | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:14:00Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:14:00Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 1791-2997 | |
dc.identifier.issn | 1791-3004 | |
dc.identifier.uri | https://dx.doi.org/10.3892/mmr_00000210 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/10030 | |
dc.description | WOS: 000270569200025 | en_US |
dc.description | PubMed ID: 21475939 | en_US |
dc.description.abstract | Accumulated evidence suggests that alterations due to mutations or genetic polymorphisms in the AXIN2 tumor suppressor gene, a component of the Wnt signaling pathway, contributes to carcinogenesis. The effect of the AXIN2 exon 1 148 C -> T polymorphism was recently investigated in a Japanese population, but has not been investigated in other populations. Additionally, other common polymorphisms of this gene have not been studied. In the present study, 8 polymorphisms of the AXIN2 gene, including exon 1 148 C -> T, were investigated in a Turkish population of 100 lung cancer patients using PCR-RFLP methods. For the exon 1 432 C -> T, exon 5 1365 G -> A, exon 5 1386 C -> T, intron 5 1712+19 G -> T, exon 7 2062 C -> T and intron 7 2141+73 G -> A single nucleotide polymorphisms of AXIN2, no significant association was found between the controls and the lung cancer patients. For exon 1 148 C -> T, a statistically significant association between the controls and lung cancer patients was found. For this region, lung cancer patients with the TT genotype showed a decreased risk [odds ratio (ORTT) 0.33, 95% confidence interval (CI) 0.12-0.89; p=0.032 (adjusted for, gender and smoking status)] as compared with the controls age. with the CC genotype. Concerning histological tumor type, it has been found that exon 1 148 C -> T SNP is associated with a significant decreased risk in squamous cell carcinoma patients (ORTT 0.16; 95% CI 0.03-0.79; p=0.014). Male (ORTT 0.19; 95% CI 0.4-0.77; p=0.015) and smoker (ORTT 0.11; 95% CI 0.01-0.71; p=0.019) lung cancer patients with the TT genotype showed a decreased risk for the same region. Our results suggest that the risk of lung cancer in a Turkish population is related to poly morph isms of the AXIN2 gene. | en_US |
dc.description.sponsorship | Cumhuriyet University CUBAP, Sivas, Turkey [T-299] | en_US |
dc.description.sponsorship | This study was supported by Grant no. T-299 from Cumhuriyet University CUBAP, Sivas, Turkey. The technical assistance of Ms. Metal Yilimaz is gratefully acknowledged. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPANDIDOS PUBL LTD | en_US |
dc.relation.isversionof | 10.3892/mmr_00000210 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | AXIN2 | en_US |
dc.subject | polymorphism | en_US |
dc.subject | lung cancer | en_US |
dc.subject | cancer predisposition | en_US |
dc.subject | Turkish population | en_US |
dc.title | Strong association between lung cancer and the AXIN2 polymorphism | en_US |
dc.type | article | en_US |
dc.relation.journal | MOLECULAR MEDICINE REPORTS | en_US |
dc.contributor.department | [Gunes, Emine Gulsen -- Pinarbasi, Ergun] Cumhuriyet Univ, Fac Med, Dept Med Biol & Genet, TR-58140 Sivas, Turkey -- [Pinarbasi, Hatice -- Silig, Yavuz] Cumhuriyet Univ, Fac Med, Dept Biochem, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 2 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.endpage | 1035 | en_US |
dc.identifier.startpage | 1029 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |