dc.contributor.author | Seckin, Y. | |
dc.contributor.author | Arici, S. | |
dc.contributor.author | Harputluoglu, M. | |
dc.contributor.author | Yonem, O. | |
dc.contributor.author | Yimaz, A. | |
dc.contributor.author | Ozer, H. | |
dc.contributor.author | Karincaoglu, M. | |
dc.contributor.author | Demirel, U. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:14:01Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:14:01Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0001-5644 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/10038 | |
dc.description | WOS: 000273799600004 | en_US |
dc.description | PubMed ID: 20163034 | en_US |
dc.description.abstract | Background and study aims : Abnormal expression of claudin-4 and beta-catenin play a role in carcinogenesis. The purpose of the present study was to examine claudin-4 and beta-catenin expression in normal and precancerous gastric mucosa. Patients and methods : Endoscopic biopsy specimens [normal gastric mucosa (n = 22), intestinal metaplasia (n = 24), dysplasia (n = 18), Helicobacter pylori (H. pylori)-associated chronic gastritis (n = 32) and remnant gastric mucosa (n = 18)] obtained from different 114 patients were examined by immunohistochemistry. Results : Claudin-4 expression was present in 94.4% of dysplasia, 87.5% of intestinal metaplasia, 62.5% H. pylori-associated chronic gastritis, and 88.9% remnant gastric mucosa but only 18.2% of normal gastric mucosa biopsies. Decreased expression of beta-catenin was present in 27.8% of dysplasia, 8.3% of intestinal metaplasia, 15.6% of H. pylori-associated chronic gastritis, and 22.2% of remnant gastric mucosa biopsies, but was not present in normal gastric mucosa. When compared with normal gastric mucosa, there was a significant difference in claudin-4 expression in all groups (P < 0.05), but a significant difference was detected in dysplasia and remnant gastric mucosa for beta-catenin (P < 0.05). Conclusions : Our results suggest that claudin-4 expression is upregulated in premalignant gastric alterations. (Acta gastroenterol. belg., 2009, 72, 407-412). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | UNIV CATHOLIQUE LOUVAIN-UCL | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | claudin-4 | en_US |
dc.subject | beta-catenin | en_US |
dc.subject | gastric epithelial dysplasia | en_US |
dc.subject | intestinal metaplasia | en_US |
dc.subject | Helicobacter pylori | en_US |
dc.title | Expression of claudin-4 and beta-catenin in gastric premalignant lesions | en_US |
dc.type | article | en_US |
dc.relation.journal | ACTA GASTRO-ENTEROLOGICA BELGICA | en_US |
dc.contributor.department | [Seckin, Y. -- Harputluoglu, M. -- Karincaoglu, M. -- Demirel, U.] Inonu Univ, Fac Med, Dept Gastroenterol, Malatya, Turkey -- [Arici, S. -- Ozer, H.] Cumhuriyet Univ, Fac Med, Dept Pathol, Sivas, Turkey -- [Yonem, O. -- Yimaz, A.] Cumhuriyet Univ, Fac Med, Dept Gastroenterol, Sivas, Turkey | en_US |
dc.identifier.volume | 72 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 412 | en_US |
dc.identifier.startpage | 407 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |