dc.contributor.author | Hasbek, Zekiye | |
dc.contributor.author | Turgut, Bulent | |
dc.contributor.author | Erselcan, Janer | |
dc.contributor.author | Yalta, Kenan | |
dc.contributor.author | Tandogan, Izzet | |
dc.contributor.author | Ozer, Gurkan | |
dc.contributor.author | Ozdemir, Umit | |
dc.contributor.author | Turgut, Nergiz Hacer | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:14:03Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:14:03Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0143-3636 | |
dc.identifier.issn | 1473-5628 | |
dc.identifier.uri | https://dx.doi.org/10.1097/MNM.0b013e32832c79b6 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/10046 | |
dc.description | WOS: 000269807700004 | en_US |
dc.description | PubMed ID: 19654563 | en_US |
dc.description.abstract | Aim The aim of this study was to evaluate the myocardial viability in nondiabetic patients with chronic coronary artery disease (CCAD) or past myocardial infarction (MI), using thallium-201 infusion myocardial perfusion single-photon emission computed tomography (MPSPECT) imaging after oral glucose application (Glu + Tl-201-infusion). Materials and methods In this study, 33 nondiabetic patients (three female, 30 male, mean age: 55.24 +/- 11 years, range: 33-77 years) with MI history or known CCAD were included. Rest/redistribution/24 h-late-MPSPECT imaging was performed for all patients. In all patients in whom fixed perfusion defect was observed on any wall of the left ventriculi, after 24 h-late-MPSPECT imaging, 75g oral glucose was given. Thirty minutes later, 1 mCi thallium-201 in 100 ml of physiological saline solution was applied in a period of 20 min by slow infusion. After infusion at the 10th minute, MPSPECT imaging was performed. Perfusion was evaluated visually for a total of 3432 segments with the 26-segment 5-point scoring technique. Scoring measured perfusion as 0=no perfusion defect, 1=mildly reduced, 2=moderately reduced, 3=severely reduced, and 4=absent uptake. Scores '0 and 1' were considered normal and scores '2-4' were considered abnormal. Results For serum insulin levels measured after glucose application, a significant increase was determined, according to the period before glucose application (P<0.001). When compared with rest MPSPECT images, segmental perfusion improvement both in redistribution and in the 24 h-late-MPSPECT images were 16.3 and 18.3%, respectively. This ratio was found to be 272% for Glu + Tl-201-infusion images. The ratios of segments in which perfusion was worsening were calculated to be 9.4, 14.5, and 7.3%, respectively, for redistribution, 24 h-late-MPSPECT, and Glu + Tl-201-infusion images. When this evaluation was made for all three vessel areas, again the highest perfusion improvement and the lowest perfusion worsening were detected for Glu + Tl-201-infusion images. In addition, when this evaluation was made for the three vessel areas according to the coronary narrowing degree, again the highest perfusion improvement was detected for Glu + Tl-201-infusion images, in segments in the left anterior descending artery, and right coronary artery areas with >= 90% narrowing. In rest images, in segments with segmental scores of 3 and 4, when the total reversibility ratio was evaluated, this ratio was calculated to be 0.7% for redistribution images and 4.5% for 24 h-late-M PSPECT. The highest total reversibility ratio in these segments was detected with Glu + Tl-201-infusion images to be 10.3%. When we evaluated the patients with respect to the MI history time, the highest segmental perfusion improvement was detected in patients with 0-3 months of MI history. Conclusion We conclude that in nondiabetic patients who are known to have CCAD or past MI history, Glu + (TI)-T-201-infusion is an easily applicable method that gives better results for the evaluation of myocardial viability. Nucl Med Commun 30:779-788 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.relation.isversionof | 10.1097/MNM.0b013e32832c79b6 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | chronic coronary artery disease | en_US |
dc.subject | myocardial perfusion single-photon emission computed tomography | en_US |
dc.subject | myocardial viability | en_US |
dc.subject | oral glucose | en_US |
dc.subject | thallium-201 infusion | en_US |
dc.title | Evaluation of myocardial viability with thallium-201 infusion MPSPECT after oral glucose application in patients with chronic coronary artery disease | en_US |
dc.type | article | en_US |
dc.relation.journal | NUCLEAR MEDICINE COMMUNICATIONS | en_US |
dc.contributor.department | [Turgut, Bulent -- Erselcan, Janer -- Ozer, Gurkan] Cumhuriyet Univ Hosp, Dept Nucl Med, TR-58140 Sivas, Turkey -- [Hasbek, Zekiye] Kahramanmaras Hosp, Dept Nucl Med, Minist Hlth, Kahramanmaras, Turkey -- [Yalta, Kenan -- Tandogan, Izzet] Cumhuriyet Univ Hosp, Dept Cardiol, Sch Med, TR-58140 Sivas, Turkey -- [Ozdemir, Umit] Sivas Numune Hosp, Minist Hlth, Dept Biochem, Sivas, Turkey | en_US |
dc.identifier.volume | 30 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.endpage | 788 | en_US |
dc.identifier.startpage | 779 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |