Efficacy of oral ribavirin treatment in Crimean-Congo haemorrhagic fever: A quasi-experimental study from Turkey
dc.contributor.author | Elaldi, Nazif | |
dc.contributor.author | Bodur, Hurrem | |
dc.contributor.author | Ascioglu, Sibel | |
dc.contributor.author | Celikbas, Aysel | |
dc.contributor.author | Ozkurt, Zulal | |
dc.contributor.author | Vahaboglu, Haluk | |
dc.contributor.author | Leblebicioglu, Hakan | |
dc.contributor.author | Yilmaz, Neziha | |
dc.contributor.author | Engin, Aynur | |
dc.contributor.author | Sencan, Mehmet | |
dc.contributor.author | Aydin, Kemalettin | |
dc.contributor.author | Dokmetas, Ilyas | |
dc.contributor.author | Cevik, Mustafa Aydin | |
dc.contributor.author | Dokuzoguz, Basak | |
dc.contributor.author | Tasyaran, Mehmet Ali | |
dc.contributor.author | Ozturk, Recep | |
dc.contributor.author | Bakir, Mehmet | |
dc.contributor.author | Uzun, Ramazan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:14:28Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:14:28Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 0163-4453 | |
dc.identifier.issn | 1532-2742 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.jinf.2009.01.014 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/10182 | |
dc.description | WOS: 000264945300010 | en_US |
dc.description | PubMed ID: 19246100 | en_US |
dc.description.abstract | Objective: The aim of this study was to evaluate the efficacy of oral ribavirin treatment in patients with Crimean-Congo haemorrhagic fever (CCHF). Methods: In 2004, all patients diagnosed with CCHF were treated with oral ribavirin, however in 2003 none of the CCHF patients had been given treatment due to Lack of confirmatory diagnostic information at that time in Turkey. In this study, patients treated with ribavirin in 2004 (n = 126) were compared with ribavirin-untreated CCHF patients (n = 92) in 2003. Patients only with a definitive diagnosis of CCHF (clinical symptoms plus the presence of specific IgM antibodies against CCHF virus and presence of viral antigen) were included in this study. Results: There was no difference in the case-fatality rate between treated and untreated patients (7.1% vs. 11.9%; P > 0.05). A Cox Proportional Hazards regression analysis revealed that altered sensorium and prolonged international normalized ratio were independent predictors of mortality. Conclusion: Our results showed that oral ribavirin treatment did not improve the survival rate in CCHF patients. Ribavirin and supportive care are the only available choices for treatment of CCHF patients, but to ascertain the efficacy of ribavirin, more laboratory and observational studies are necessary and ultimately, to elucidate these conflicting results and evaluate the efficacy undoubtedly, a multicenter randomised controlled trial will be needed. (C) 2009 The British Infection Society. Published by Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | Turkish Ministry of Health | en_US |
dc.description.sponsorship | We would like to thank our colleagues from the Turkish Ministry of Health for their contributions. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | W B SAUNDERS CO LTD | en_US |
dc.relation.isversionof | 10.1016/j.jinf.2009.01.014 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Crimean-Congo haemorrhagic fever | en_US |
dc.subject | Oral ribavirin treatment | en_US |
dc.subject | Case-fatality rate | en_US |
dc.title | Efficacy of oral ribavirin treatment in Crimean-Congo haemorrhagic fever: A quasi-experimental study from Turkey | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF INFECTION | en_US |
dc.contributor.department | [Ascioglu, Sibel] Hacettepe Univ, Sch Med, Dept Internal Med, Infect Dis Sect, TR-06100 Ankara, Turkey -- [Elaldi, Nazif -- Engin, Aynur -- Dokmetas, Ilyas -- Bakir, Mehmet] Cumhuriyet Univ, Dept Infect Dis & Clin Bacteriol, TR-58140 Sivas, Turkey -- [Bodur, Hurrem -- Celikbas, Aysel -- Cevik, Mustafa Aydin -- Dokuzoguz, Basak] Ankara Numune Training & Res Hosp, Dept Infect Dis & Clin Bacteriol, TR-06100 Ankara, Turkey -- [Ascioglu, Sibel] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA -- [Ozkurt, Zulal -- Tasyaran, Mehmet Ali] Ataturk Univ, Dept Infect Dis & Clin Bacteriol, TR-25240 Erzurum, Turkey -- [Vahaboglu, Haluk] Kocaeli Univ, Dept Infect Dis & Clin Bacteriol, TR-41380 Umuttepe, Kocaeli, Turkey -- [Leblebicioglu, Hakan] Ondokuz Mayis Univ, Dept Infect Dis & Clin Bacteriol, TR-55200 Kurupelit, Samsun, Turkey -- [Yilmaz, Neziha -- Uzun, Ramazan] Refik Saydam Hifzisihha Inst, TR-06100 Ankara, Turkey -- [Sencan, Mehmet] Cumhuriyet Univ, Dept Internal Med, TR-58140 Sivas, Turkey -- [Aydin, Kemalettin] Karadeniz Tech Univ, Dept Infect Dis & Clin Bacteriol, TR-61080 Trabzon, Turkey -- [Ozturk, Recep] Univ Istanbul, Dept Infect Dis & Clin Bacteriol, TR-34303 Istanbul, Turkey | en_US |
dc.contributor.authorID | Leblebicioglu, Hakan -- 0000-0002-6033-8543; Ascioglu, Sibel -- 0000-0002-6052-029X; VAHABOGLU, Haluk -- 0000-0001-8217-1767; Elaldi, Nazif -- 0000-0002-9515-770X; dokmetas, ilyas -- 0000-0003-3523-3923 | en_US |
dc.identifier.volume | 58 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.endpage | 244 | en_US |
dc.identifier.startpage | 238 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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