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dc.contributor.authorArici, D. S.
dc.contributor.authorTuncer, E.
dc.contributor.authorOzer, H.
dc.contributor.authorSimek, G.
dc.contributor.authorKoyuncu, A.
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:14:44Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:14:44Z
dc.date.issued2009
dc.identifier.issn0028-2685
dc.identifier.issn1338-4317
dc.identifier.urihttps://dx.doi.org/10.4149/neo_2009_01_63
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10251
dc.descriptionWOS: 000262614200010en_US
dc.descriptionPubMed ID: 19152247en_US
dc.description.abstractAbnormal regulation of the cell cycle is a feature of many neoplasms. The role of cell cycle regulators in oncogenesis has been investigated in many human tumors. Alteration of the retinoblastoma (pRb) and cyclin D1 disrupt the Rb pathway and occur in many carcinomas. However the expression of the Rh and cyclin D1 in intestinal type gastric carcinoma is unclear. The purpose of this study was to investigate the expression of Rb and cyclin D1 in resected gastric carcinoma, their adjacent nonneoplastic mucosa and normal gastric mucosa, and finally to provide insights into the role of the Rb and cyclin D1 in gastric carcinogenesis. We investigated Rb and cyclin D1 expression in 43 patients (32 men, 11 women; mean age: 64) with primary gastric adenocarcinoma and compared the results with adjacent nonneoplastic mucosa. Adjacent nonneoplastic mucosa)Sa consisted of atrophy, dysplasia, intestinal metaplasia and gastritis. Expression of Rb was detected in 30 (69.7%) of gastric carcinoma, 18 (41.8%) of the adjacent nonneoplastic mucosa. Expression of cyclin D1 protein was detected in 31 (72%) of gastric carcinoma. 24 (55.8%) of adjacent nonneoplastic mucosa. Expression of Rh and cyclin D1 was not detected in normal gastric mucosa. The positive rate of Rb and cyclin D1 expression in gastric carcinoma was significantly higher than that adjacent nonneoplastic mucosa (p<0.05). There were significant trends for increased expression of Rb and cyclin D1 from nonneoplastic mucosa including atrophy, dyplasia, intestinal metaplasia and gastritis to carcinoma. These results suggested that positive expression of pRb and cyclin D1 might be an early event in gastric carcinoma and it tend to begin at precursor lesions and maintain throughout the progression of infiltration.en_US
dc.language.isoengen_US
dc.publisherAEPRESS SROen_US
dc.relation.isversionof10.4149/neo_2009_01_63en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRetinoblastomaen_US
dc.subjectcyclin D1en_US
dc.subjectgastric carcinomaen_US
dc.subjectdisplasiaen_US
dc.subjectatrophyen_US
dc.subjectintestinal metaplasiaen_US
dc.titleExpression of retinoblastoma and cyclin D1 in gastric carcinomaen_US
dc.typearticleen_US
dc.relation.journalNEOPLASMAen_US
dc.contributor.department[Arici, D. S. -- Tuncer, E. -- Ozer, H. -- Simek, G.] Cumhuriyet Univ, Sch Med, Dept Pathol, TR-58140 Sivas, Turkey -- [Koyuncu, A.] Cumhuriyet Univ, Sch Med, Dept Gen Surg, TR-58140 Sivas, Turkeyen_US
dc.identifier.volume56en_US
dc.identifier.issue1en_US
dc.identifier.endpage67en_US
dc.identifier.startpage63en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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