dc.contributor.author | Koyuncu, Ayhan | |
dc.contributor.author | Bagcivan, Ihsan | |
dc.contributor.author | Sarac, Bulent | |
dc.contributor.author | Aydin, Cengiz | |
dc.contributor.author | Yildirim, Sahin | |
dc.contributor.author | Sarioglu, Yusuf | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:15:04Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:15:04Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 1007-9327 | |
dc.identifier.uri | https://dx.doi.org/10.3748/wjg.14.4667 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/10331 | |
dc.description | WOS: 000258544500010 | en_US |
dc.description | PubMed ID: 18698681 | en_US |
dc.description.abstract | AIM: To investigate the tolerance development against the relaxant effect of nitric oxide donating drug isosorbide dinitrate (ISDN) and sodium nitropruside (SNP) in internal anal sphincter (IAS) smooth muscle. METHODS: Relaxation responses of ISDN, and electrical field stimulation (EFS) were obtained before and after tolerance induction by ISDN incubation. RESULTS: ISDN (10(-7)-10(-7) mol/L) and SNP (10(-8)-10(-4) mol/L caused a concentration-dependent relaxation on the basal tonus of the isolated rabbit IAS strips. After a period of 2 h incubation of the 6 x 10(-4) mol/L ISDN the relaxation effects of ISDN and SNP did not change compared to control strips. EFS evoked frequency-dependent relaxation in internal anal sphincter smooth muscle and E(max) obtained from control strips were not changed in ISDN tolerance-inducing condition. In this study nitrate tolerance was not observed in rabbit IAS smooth muscle. CONCLUSION: This result shows that nitric oxide donating drugs relaxes the internal anal sphincter of the rabbits without the development of tolerance. (c) 2008 The WIG Press. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BAISHIDENG PUBL GRP CO LTD | en_US |
dc.relation.isversionof | 10.3748/wjg.14.4667 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | internal anal sphincter | en_US |
dc.subject | nitrate tolerance | en_US |
dc.title | Lack of nitrate tolerance in isosorbid dinitrate- and sodium nitroprusside-induced relaxation of rabbit internal anal sphincter | en_US |
dc.type | article | en_US |
dc.relation.journal | WORLD JOURNAL OF GASTROENTEROLOGY | en_US |
dc.contributor.department | [Koyuncu, Ayhan] Cumhuriyet Univ, Sch Med, Dept Gen Surg, Fac Med, TR-58140 Sivas, Turkey -- [Bagcivan, Ihsan -- Sarac, Bulent -- Yildirim, Sahin] Cumhuriyet Univ, Fac Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- [Sarioglu, Yusuf] Gazi Univ, Dept Pharmacol, Fac Med, TR-06500 Ankara, Turkey | en_US |
dc.contributor.authorID | SARIOGLU, YUSUF -- 0000-0002-9227-365X | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 29 | en_US |
dc.identifier.endpage | 4671 | en_US |
dc.identifier.startpage | 4667 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |