dc.contributor.author | Er, Kuersat | |
dc.contributor.author | Polat, Zuebeyde Akin | |
dc.contributor.author | Oezan, Fatih | |
dc.contributor.author | Tasdemir, Tamer | |
dc.contributor.author | Sezer, Ufuk | |
dc.contributor.author | Siso, Seyda Herguener | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:15:06Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:15:06Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0929-6646 | |
dc.identifier.issn | 1876-0821 | |
dc.identifier.uri | https://dx.doi.org/10.1016/S0929-6646(08)60178-3 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/10340 | |
dc.description | WOS: 000258427600004 | en_US |
dc.description | PubMed ID: 18678544 | en_US |
dc.description.abstract | Background/Purpose: The aim of this study was to analyze the cytotoxicity of strontium ranelate (SR) on human periodontal ligament fibroblasts (PDL cells) in vitro. Methods: PDL cells were obtained from healthy human third molars and cultured in Dulbecco's Modified Eagle's Medium. The experimental groups were: G1, cultures treated with fresh medium (control); and G2, G3, G4 and G5: treated with SR at 20, 10, 5 and 2.5 mg/mL, respectively. The experimental times were 1, 6, 12 and 24 hours (short-term) for viability and 2, 4, 6 and 8 days (long-term) for cell survival. The cells were counted using a hemocytometer. Data were then analyzed by one-way ANOVA and Tukey's tests (p < 0.05). Results: Cultures treated with the highest SR concentrations (G2 and G3) had significantly lower cell viability and cell numbers (p < 0.05) than those in G1, G4 and G5. SR at 2.5 mg/mL was non-cytotoxic to PDL cells. Conclusion: SR was non-toxic at appropriate concentrations. Preclinical tests are needed to further assess its safety and effectiveness for tooth resorption prior to clinical use. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER TAIWAN | en_US |
dc.relation.isversionof | 10.1016/S0929-6646(08)60178-3 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | cell culture | en_US |
dc.subject | cytotoxicity | en_US |
dc.subject | resorption | en_US |
dc.subject | strontium ranelate | en_US |
dc.subject | trauma | en_US |
dc.title | Cytotoxicity analysis of strontium ranelate on cultured human periodontal ligament fibroblasts: A preliminary report | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION | en_US |
dc.contributor.department | [Er, Kuersat -- Tasdemir, Tamer] Karadeniz Tech Univ, Dept Endodont, Sch Dent, TR-61080 Trabzon, Turkey -- [Sezer, Ufuk] Karadeniz Tech Univ, Dept Periodontol, Sch Dent, TR-61080 Trabzon, Turkey -- [Polat, Zuebeyde Akin] Cumhuriyet Univ, Sch Med, CUTFAM Res Ctr, Sivas, Turkey -- [Oezan, Fatih] Cumhuriyet Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Sivas, Turkey -- [Siso, Seyda Herguener] Cumhuriyet Univ, Sch Dent, Dept Restorat Dent, Sivas, Turkey | en_US |
dc.contributor.authorID | Tasdemir, Tamer -- 0000-0001-8512-5280; OZAN, FATIH -- 0000-0002-0073-3170; Er, Kursat -- 0000-0002-0667-4909 | en_US |
dc.identifier.volume | 107 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.endpage | 615 | en_US |
dc.identifier.startpage | 609 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |