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dc.contributor.authorTurgut, Nergiz Hacer
dc.contributor.authorTemiz, Tijen Kaya
dc.contributor.authorBagcivan, Ihsan
dc.contributor.authorTurgut, Butent
dc.contributor.authorGulturk, Sefa
dc.contributor.authorKaradas, Baris
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:15:08Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:15:08Z
dc.date.issued2008
dc.identifier.issn0014-2999
dc.identifier.issn1879-0712
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejphar.2008.04.034
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10348
dc.descriptionWOS: 000258628400032en_US
dc.descriptionPubMed ID: 18538317en_US
dc.description.abstractThe pathophysiology of pre-eclampsia is still unknown thus effective primary prevention is not possible at the stage. The present study was conducted to research the smooth muscle responses in the pre-eclampsia model with suramin treated rats and the effect of phosphodiesterase-5 (PDE5) inhibitor on these responses. Rats of three groups; control, suramin and suramin+sildenafil were given intraperitoneal injections of saline, suramin or sildenafil citrate. Suramin injections caused increased blood pressure, protein in urine and caused fetal growth retardation.The use of sildenafil citrate straightened significantly both blood pressure and average fetus weight, but did not reach to control values. At the end of pregnancy, thoracic aorta rings were exposed to contractile and relaxant agents. KCl contraction responses, sodium nitroprusside and papaverine relaxation responses were similar in three groups. Contraction responses of phenylephrine, increased significantly in suramin group. Relaxation responses of acethylcholine and bradykinin decreased in suramin group. The use of sildenafil citrate partially straightened both relaxation and contraction responses, but did not reach to control values. In all groups in the presence of L-nitromonomethylarginine (L-NAME), 1H-(1, 2, 4) oxadiazole (4, 3-a) guinoxalin-1-one (ODQ) and indomethacin decreased the relaxation responses of acetylcholine and bradykinin. The cyclic guanosine monophosphate (cGMP) content of thoracic aorta tissue was determined by radioimmunoassay technique. The content of cGMP in suramin group decreased and use of sildenafil citrate increased the cGMP content but did not reach to control values. We conclude that in pre-eclampsia, the increase of contraction responses, the decrease of relaxation responses and the decrease of cGMP content can depend on insufficiency about synthesis or release of relaxant factors which was released from the vessel endothelium. The results in this study show that in pre-eclampsia: PDE5 inhibitors enhance endothelial function and may be used for protection. Further studies are needed to clear the efficiency and safety of PDE5 inhibitors. (c) 2008 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipCumhuriyet University Scientific Research [T-282]en_US
dc.description.sponsorshipThis study was supported by Cumhuriyet University Scientific Research Project T-282 (CUBAP, Sivas, Turkey).en_US
dc.language.isoengen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.isversionof10.1016/j.ejphar.2008.04.034en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpre-eclampsiaen_US
dc.subjectendothelial dysfunctionen_US
dc.subjectphosphodiesterase-5 inhibitoren_US
dc.subject(rat)en_US
dc.titleThe effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia modelen_US
dc.typearticleen_US
dc.relation.journalEUROPEAN JOURNAL OF PHARMACOLOGYen_US
dc.contributor.department[Turgut, Nergiz Hacer] Cumhuriyet Univ, Inst Hlth Sci, Dept Pharmacol, TR-58140 Sivas, Turkey -- [Temiz, Tijen Kaya -- Bagcivan, Ihsan] Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- [Turgut, Butent] Cumhuriyet Univ, Sch Med, Dept Nucl Med, TR-58140 Sivas, Turkey -- [Gulturk, Sefa] Cumhuriyet Univ, Sch Med, Dept Physiol, TR-58140 Sivas, Turkey -- [Karadas, Baris] Minist Hlth, Izmir Ataturk Training & Res Hosp, TR-35360 Izmir, Turkeyen_US
dc.identifier.volume589en_US
dc.identifier.issue01.Maren_US
dc.identifier.endpage187en_US
dc.identifier.startpage180en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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