dc.description.abstract | BACKGROUND At present, various hyaluronic acids are being used to rejuvenate facial skin. There is no comparative study of single cross-linked hyaluronic acid (SCHA) versus double cross-linked hyaluronic acid (DCHA). The objective of our study is to compare the effectiveness and complications of SCHA versus DCHA in the treatment of glabellar lines. METHODS Ten female patients were enrolled in this randomized, evaluator-blind study. One side (left vs. right) of each patient's glabellar lines was treated with SCHA and the other side was treated with DCHA. Two independent blinded observers reviewed the clinical photographs at 3, 6, 9, and 12 months after the treatment and assessed for degree of improvement as well as complications. RESULTS The two products were equally effective in producing an optimal cosmetic result, although at 6, 9, and 12 months posttreatment, a higher proportion of patients showed over 50% improvement with DCHA than with SCHA. At 12 months posttreatment, DCHA was considered superior in 70% of patients, whereas SCHA was superior in 10% of patients. CONCLUSIONS Both SCHA and DCHA are equally effective in producing an optimal cosmetic result. DCHA provides a more durable esthetic improvement when compared to SCHA in the treatment of glabellar lines. | en_US |
dc.contributor.department | [Kono, Taro] Tokyo Womens Med Univ, Dept Plast & Reconstruct Surg, Shinjuku Ku, Tokyo 1628666, Japan -- [Kinney, Brian M. -- Nozaki, Motohiro] Univ Calif Los Angeles, Dept Plast Surg, Los Angeles, CA USA -- [Groff, William Frederick] La Jolla Cosmet Surg Ctr, Div Cosmet Dermatol, La Jolla, CA USA -- [Chan, Henry H.] Univ Hong Kong, Dept Med, Div Dermatol, Hong Kong, Hong Kong, Peoples R China -- [Chan, Henry H.] Chinese Univ Hong Kong, Dept Med Therapeut & Pediat, Hong Kong, Hong Kong, Peoples R China -- [Ercocen, Ali Riza] Cumhuriyet Univ, Fac Med, Dept Plast Reconstruct & Aesthet Surg, Sivas, Turkey | en_US |