dc.contributor.author | Toker, Hulya | |
dc.contributor.author | Poyraz, Omer | |
dc.contributor.author | Eren, Kaya | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:15:15Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:15:15Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0303-6979 | |
dc.identifier.issn | 1600-051X | |
dc.identifier.uri | https://dx.doi.org/10.1111/j.1600-051X.2008.01213.x | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/10371 | |
dc.description | WOS: 000255700800007 | en_US |
dc.description | PubMed ID: 18371054 | en_US |
dc.description.abstract | Aim:The aim of this study was to examine the effect of phase I periodontal treatment on the levels of interleukin (IL)-1 beta, IL-1ra, and IL-10 in gingival crevicular fluid (GCF) in patients with generalized aggressive periodontitis (G-AgP). Material and Methods: Data were obtained from 15 patients with aggressive periodontitis and 15 healthy controls. GCF was collected from at least four pre-selected sites (one shallow, at least two moderate, or at least one deep pockets) in patients with G-AgP. In the healthy group, GCF samples were collected from one site. The cytokine levels were determined by an enzyme-linked immunosorbent assay. Probing depth, clinical attachment level (CAL), gingival and plaque indices, and bleeding on probing were measured. The GCF sampling and clinical measurements were recorded at baseline and 6 weeks later after periodontal treatment. Results: IL-1 beta levels were significantly higher at the moderate and deep pocket sites compared with the shallow sites (p < 0.05). After periodontal therapy, IL-1 beta levels were significantly reduced in the moderate and deep pocket sites (p<0.05). IL-1ra levels at baseline of the moderate and deep pocket sites were significantly lower than the control sites (p < 0.05). IL-10 levels were similar in all pockets and did not change after periodontal therapy. Conclusions: The periodontal treatment improves the clinical parameters in G-AgP, and this improvement is evident in deep pocket sites for pocket depth and CAL values. These results confirm that IL-1 beta is effective for evaluating the periodontal inflammation and can thus be used as a laboratory tool for assessing the activity of periodontal disease. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | WILEY | en_US |
dc.relation.isversionof | 10.1111/j.1600-051X.2008.01213.x | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | aggressive periodontitis | en_US |
dc.subject | crevicular fluid | en_US |
dc.subject | cytokine | en_US |
dc.subject | IL-1 | en_US |
dc.subject | IL-10 | en_US |
dc.title | Effect of periodontal treatment on IL-1 beta, IL-1ra, and IL-10 levels in gingival crevicular fluid in patients with aggressive periodontitis | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF CLINICAL PERIODONTOLOGY | en_US |
dc.contributor.department | [Toker, Hulya] Cumhuriyet Univ, Fac Dent, Dept Periodontol, TR-58140 Sivas, Turkey -- [Poyraz, Omer] Cumhuriyet Univ, Fac Dent, Dept Microbiol, Sivas, Turkey -- [Eren, Kaya] Gazi Univ, Fac Dent, Dept Periodontol, Ankara, Turkey | en_US |
dc.identifier.volume | 35 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.endpage | 513 | en_US |
dc.identifier.startpage | 507 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |