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dc.contributor.authorTanriverdi, F.
dc.contributor.authorAlp, E.
dc.contributor.authorDemiraslan, H.
dc.contributor.authorDokmetas, H. S.
dc.contributor.authorUnluhizarci, K.
dc.contributor.authorDoganay, M.
dc.contributor.authorCasanueva, F. F.
dc.contributor.authorKelestimur, F.
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:15:16Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:15:16Z
dc.date.issued2008
dc.identifier.issn1720-8386
dc.identifier.urihttps://dx.doi.org/10.1007/BF03346395
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10372
dc.descriptionWOS: 000257720500001en_US
dc.descriptionPubMed ID: 18591878en_US
dc.description.abstractObjective: Although long-term pituitary consequences of tuberculous meningitis are well documented in the literature, there have been few case reports of pituitary dysfunction after acute bacteria[ or viral meningitis. In this preliminary study, we have assessed the pituitary functions in adult patients who had acute bacterial or viral meningitis. Design and methods: Fourteen patients (8 men, 6 women; mean age 35.3 +/- 13.3) were included in the study. The diagnosis of bacterial and viral meningitis was proven by clinical findings, cerebrospinal fluid (CSF) examination, gram staining, and blood and CSF cultures. Pituitary functions were evaluated ranging from 6 to 48 months (mean 20 months) after acute meningitis. GH deficiency was investigated by the GHRH+arginine stimulation test. Results: Four of 14 patients (28.6%) had isolated GH deficiency. In GH-deficient patients, the earliest duration was 6 months and the latest duration was 48 months after the diagnosis of acute meningitis. Three of the GH-deficient patients had acute bacterial meningitis and I patient had acute viral meningitis. Pituitary magnetic resonance imaging revealed normal pituitary gland in the patients with GH deficiency. Conclusions: This is the first systematic study evaluating the anterior pituitary function long term after the diagnosis of acute meningitis. Based on the present study, it is tempting to speculate that pituitary dysfunction is a more common sequel of acute bacterial or viral meningitis than hitherto reported. Studies with high numbers of patients are warranted to ascertain the prevalence of meningitis-induced hypopituitarism.en_US
dc.language.isoengen_US
dc.publisherSPRINGERen_US
dc.relation.isversionof10.1007/BF03346395en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGH deficiencyen_US
dc.subjectGHRH plus arginineen_US
dc.subjecthypopituitarismen_US
dc.subjectmeningitisen_US
dc.subjectpituitaryen_US
dc.titleInvestigation of pituitary functions in patients with acute meningitis: A pilot studyen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF ENDOCRINOLOGICAL INVESTIGATIONen_US
dc.contributor.department[Tanriverdi, F. -- Unluhizarci, K. -- Kelestimur, F.] Erciyes Univ, Sch Med, Dept Endocrinol, TR-38039 Kayseri, Turkey -- [Alp, E. -- Demiraslan, H. -- Doganay, M.] Erciyes Univ, Sch Med, Dept Infect Dis, TR-38039 Kayseri, Turkey -- [Dokmetas, H. S.] Cumhuriyet Univ, Sch Med, Dept Endocrinol, Sivas, Turkey -- [Casanueva, F. F.] Univ Santiago de Compostela, Sch Med, Dept Med, Santiago De Compostela, Spain -- [Casanueva, F. F.] Univ Santiago de Compostela, Complejo Hosp Univ Santiago, Santiago De Compostela, Spainen_US
dc.identifier.volume31en_US
dc.identifier.issue6en_US
dc.identifier.endpage491en_US
dc.identifier.startpage489en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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