dc.contributor.author | Turkay, Cansel | |
dc.contributor.author | Yonem, Ozlem | |
dc.contributor.author | Arici, Sema | |
dc.contributor.author | Koyuncu, Ayhan | |
dc.contributor.author | Kanbay, Mehmet | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:15:29Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:15:29Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0163-2116 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s10620-007-9941-y | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/10417 | |
dc.description | WOS: 000253570700029 | en_US |
dc.description | PubMed ID: 17763951 | en_US |
dc.description.abstract | The renin-angiotensin system is suggested to be important in liver fibrogenesis. It induces hepatic stellate cell proliferation and up-regulates transforming growth factor beta-1 (TGF-beta 1) expression. Matrix metalloproteinase-2 (MMP-2) is involved in extracellular matrix remodelling. Fibrosis, a consequence of most chronic liver diseases, may be the result of a disturbed balance between fibrogenesis and fibrolysis. The aim of this study was to investigate the effect of enalapril on liver fibrogenesis induced in rats by bile-duct ligation. Forty-seven rats were divided into two groups: bile-duct ligated (BDL) (n = 24) and BDL + enalapril (n = 23). Fibrosis was evaluated by the Knodell scoring system, and TGF-beta 1 and MMP-2 were assessed with immunohistochemistry at the second, fourth and sixth weeks after bile-duct ligation. In the BDL group, TGF-beta 1 increased by the second week and this increase continued through weeks 4 and 6. In the BDL + enalapril group, TGF-beta 1 was significantly lower than the other group (P < 0.05). MMP-2 progressively decreased after week 2 in the BDL group. In the BDL + enalapril group, MMP-2 was significantly higher than the BDL group at the fourth and sixth weeks. These results suggest that enalapril reduces the liver tissue TGF-beta 1 and has an ameliorating effect on the fibrosis markers TGF-beta 1 and MMP-2. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER | en_US |
dc.relation.isversionof | 10.1007/s10620-007-9941-y | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | enalapril | en_US |
dc.subject | transforming growth factor beta-1 | en_US |
dc.subject | matrix metalloproteinase-2 | en_US |
dc.title | Effect of angiotensin-converting enzyme inhibition on experimental hepatic fibrogenesis | en_US |
dc.type | article | en_US |
dc.relation.journal | DIGESTIVE DISEASES AND SCIENCES | en_US |
dc.contributor.department | [Kanbay, Mehmet] Fatih Univ, Dept Internal Med, Fac Med, Ankara, Turkey -- [Turkay, Cansel] Fatih Univ, Dept Gastroenterol, Fac Med, Ankara, Turkey -- [Yonem, Ozlem] Cumhuriyet Univ, Dept Internal Med, Fac Med, Sivas, Turkey -- [Arici, Sema] Cumhuriyet Univ, Dept Pathol, Fac Med, Sivas, Turkey -- [Koyuncu, Ayhan] Cumhuriyet Univ, Dept Surg, Fac Med, Sivas, Turkey | en_US |
dc.identifier.volume | 53 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.endpage | 793 | en_US |
dc.identifier.startpage | 789 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |