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dc.contributor.authorGursoy, Ulvi Kahraman
dc.contributor.authorSokucu, Oral
dc.contributor.authorUitto, Veli-Jukka
dc.contributor.authorAydin, Ahmet
dc.contributor.authorDemirer, Serhat
dc.contributor.authorToker, Hulya
dc.contributor.authorErdem, Onur
dc.contributor.authorSayal, Ahmet
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:15:54Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:15:54Z
dc.date.issued2007
dc.identifier.issn0141-5387
dc.identifier.urihttps://dx.doi.org/10.1093/ejo/cjm074
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10490
dc.descriptionWOS: 000251506100003en_US
dc.descriptionPubMed ID: 17989122en_US
dc.description.abstractThe aim of this study was to investigate the role of nickel in orthodontic treatment-induced gingival hyperplasia. The nickel concentration in gingival tissues with and without overgrowth, histopathology of gingival overgrowths, and epithelial cell proliferation response to different nickel concentrations were analysed. Ten patients receiving orthodontic therapy (eight females and two males, mean age 15.4 years) were included in the study. Hyperplastic and healthy gingiva samples were collected from the same patients. The amount of nickel in the gingival tissue samples was analysed using the atomic absorption spectrometry technique. The tissues removed from hyperplastic areas during gingivectomy were also used for histological analysis. To analyse the effect of nickel on epithelial cell proliferation, four different nickel concentrations (0.5, 2, 5, and 10 mu g) were incubated with keratinocyte cells for 11 days. Mann-Whitney U-test, analysis of variance, and Tukey's test were used in the statistical analyses. The results did not show any difference in nickel concentration between the study and control gingiva tissue samples, but histological analysis demonstrated an increase in epithelial thickness and a significant increase (P = 0.031, 0.02, 0.02) in epithelial cell proliferation in response to low-dose nickel concentrations, with a toxic response to a higher dose. In the limitations of this study, it is plausible that the effect of a continuing low-dose nickel release to epithelium is the initiating factor of gingival overgrowth induced by orthodontic treatment.en_US
dc.language.isoengen_US
dc.publisherOXFORD UNIV PRESSen_US
dc.relation.isversionof10.1093/ejo/cjm074en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe role of nickel accumulation and epithelial cell proliferation in orthodontic treatment-induced gingival overgrowthen_US
dc.typearticleen_US
dc.relation.journalEUROPEAN JOURNAL OF ORTHODONTICSen_US
dc.contributor.departmentUniv Helsinki, Cent Hosp, Inst Dent, Dept Oral & Maxillofacial Surg, Helsinki, Finland -- Cumhuriyet Univ, Dept Periodont, Sivas, Turkey -- Cumhuriyet Univ, Dept Orthodont, Sivas, Turkey -- Gulhane Mil Med Acad, Dept Toxicol, Ankara, Turkey -- Kirikkale Univ, Dept Periodontol, Kirikkale, Turkeyen_US
dc.contributor.authorIDGursoy, Ulvi Kahraman -- 0000-0002-1225-5751en_US
dc.identifier.volume29en_US
dc.identifier.issue6en_US
dc.identifier.endpage558en_US
dc.identifier.startpage555en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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