dc.contributor.author | Cevit, Omer | |
dc.contributor.author | Bagcivan, Ihsan | |
dc.contributor.author | Sarac, Bulent | |
dc.contributor.author | Parlak, Ahmet | |
dc.contributor.author | Durmus, Nedim | |
dc.contributor.author | Kava, Tiien | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:16:22Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:16:22Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0014-2999 | |
dc.identifier.issn | 1879-0712 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.ejpliar.2007.03.049 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/10568 | |
dc.description | WOS: 000247281700021 | en_US |
dc.description | PubMed ID: 17499241 | en_US |
dc.description.abstract | Nicotine is an irritant molecule in the cigarette that contributes airway hyper-reactivity. The aim of this study was to investigate the mechanism of these effects and effects of nicotine on the isolated trachea preparations from control and ovalbumin-sensitized guinea-pigs. Nicotine (3 x 10(-5) to 3 x 10(-4) M) produced concentration-dependent relaxation on isolated trachea preparations precontracted by carbachol (10(-6) M) in both groups. We found that the relaxant effect of nicotine decreased in the presence of N(w)-nitro L-arginine methyl ester (L-NAME) (10(-6) M), and hexamethonium (10(-2) M) but not in the presence of alpha-bungarotoxin (10(-3) M), and tetrodotoxin (3.1 x 10(-6) M) in isolated trachea preparations in both groups. The relaxant effect of nicotine was less significant in isolated trachea preparations from ovalbumin-sensitized guinea-pigs than from control guinea-pigs (P < 0.05). The contractions elicited by carbachol (10(-6) M) were not significantly different in the ovalbumin-sensitized group than in the control group. Nicotine (10(-4) M) Significantly increased the cGMP levels in trachea preparations compared with the control preparations. (P < 0.05). These results suggest that nicotine-induced relaxation response in normal and ovalbumin sensitized guinea-pigs trachea is at least in part mediated by nitric oxide (NO) since it was significantly reduced in the presence of L-NAME. The decreased relaxation response to nicotine in ovalbumin sensitized guinea-pigs trachea may be due to impaired production and/or liberation of NO. (c) 2007 Elsevier B.V. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.relation.isversionof | 10.1016/j.ejpliar.2007.03.049 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | nicotine | en_US |
dc.subject | trachea | en_US |
dc.subject | ovalbumin sensitized guinea-pig | en_US |
dc.title | Mechanism of relaxation induced by nicotine in normal and ovalbumin-sensitized guinea-pig trachea | en_US |
dc.type | article | en_US |
dc.relation.journal | EUROPEAN JOURNAL OF PHARMACOLOGY | en_US |
dc.contributor.department | Cumhuriyet Univ, Sch Med, Dept Pediat, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 567 | en_US |
dc.identifier.issue | 01.Feb | en_US |
dc.identifier.endpage | 154 | en_US |
dc.identifier.startpage | 149 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |