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dc.contributor.authorYildiz, Turan
dc.contributor.authorKoyluoglu, Gokhan
dc.contributor.authorBagcivan, Ihsan
dc.contributor.authorKaya, Tijen
dc.contributor.authorKaradas, Bans
dc.contributor.authorSarac, Buelent
dc.contributor.authorCankorkmaz, Levent
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:16:25Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:16:25Z
dc.date.issued2007
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.urihttps://dx.doi.org/10.1016/j.jpedsurg.2007.02.011
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10577
dc.descriptionWOS: 000248692800010en_US
dc.descriptionPubMed ID: 17618883en_US
dc.description.abstractBackground/ Purpose: The aim of this study was to investigate the effect of peritonitis on spontaneous contractions of distal and proximal colon smooth muscle isolated from rats. Methods: Peritonitis was induced by cecal ligation and puncture in 8 rats. Another group of 8 rats : underwent a sham operation and acted as controls. Twenty-four hours after the operation, the rats were killed; and their distal and proximal colon smooth muscle was excised and placed in circular muscle direction in a 10-mL organ bath. Changes in the amplitude and frequency of contractions were analyzed before and after the addition of antagonists. Results: Peritonitis induced the increase in the amplitude and frequency of spontaneous contractions. In both distal and proximal colon of the control group, the amplitude of spontaneous contractions was elevated by N-G -nitro-L-arginine and tetradotoxin; but the frequency of spontaneous contractions was significantly elevated only in the presence of N-G-nitro-L-arginine. In both distal and proximal colon of the peritonitis group, the enhanced amplitude and frequency were significantly decreased and returned to control values in the presence of celecoxib. Conclusions: Peritonitis induces the increase in the amplitude and frequency of spontaneous contractions of distal and proximal colon, which can be attributed to a loss of inhibitor nitrergic and other neural control or rise of cyclooxygenase-2 levels. (c) 2007 Elsevier Inc. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherW B SAUNDERS CO-ELSEVIER INCen_US
dc.relation.isversionof10.1016/j.jpedsurg.2007.02.011en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectperitonitisen_US
dc.subjectsmooth muscleen_US
dc.subjectCOX-2en_US
dc.subjectspontaneous contractionsen_US
dc.titleAlterations in spontaneous contractions of rat proximal and distal colon after peritonitisen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF PEDIATRIC SURGERYen_US
dc.contributor.departmentCumhuriyet Univ, Fac Med, Dept Pediat Surg, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Fac Med, Dept Pharmacol, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDKoyluoglu, Gokhan -- 0000-0002-1140-169Xen_US
dc.identifier.volume42en_US
dc.identifier.issue7en_US
dc.identifier.endpage1220en_US
dc.identifier.startpage1215en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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