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dc.contributor.authorKaradas, Baris
dc.contributor.authorKaya, Tijen
dc.contributor.authorCetin, Meral
dc.contributor.authorParlak, Ahmet
dc.contributor.authorDurmus, Nedim
dc.contributor.authorBagcivan, Ihsan
dc.contributor.authorGulturk, Sefa
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:16:43Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:16:43Z
dc.date.issued2007
dc.identifier.issn1537-1891
dc.identifier.issn1879-3649
dc.identifier.urihttps://dx.doi.org/10.1016/j.vph.2006.12.002
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10622
dc.description8th International Conference on Vascular Endothelium -- JUN 25-JUL 02, 2005 -- Iraklion, GREECEen_US
dc.descriptionWOS: 000245663400013en_US
dc.descriptionPubMed ID: 17229593en_US
dc.description.abstractAlterations in vascular responses to beta-adrenoceptor agonists in normotensive pregnancy and pre-eclampsia are not fully understood. Thus, we studied changes in vasodilator responses to beta(2)-adrenoceptor agonist formoterol and beta(3)-adrcnoceptor agonist BRL 37344 on umbilical arteries isolated from normotensive (n = 12) and pre-eclamptic (n = 12) pregnant women. Changes in the relaxant effect of formoterol and BRL 37344 were investigated by measuring isometric tensions in endothelium-denuded strips of umbilical arteries in the presence or absence of metoprolol, ICI 118.551 and SR 59230A (beta(1), beta(2), beta(3)-adrenoceptor antagonists, respectively, 10(-6) mol/L). Effects of formoterol and BRL 37344 on cAMP levels of umbilical arteries were evaluated by radioimmunoassay kits. Formoterol (10(-10)-10(-4) mol/L) and BRL 37344 (10(-10)-10(-4) men) caused concentration-dependent relaxation of the contraction induced by phenylephrine (10(-5) mol/L) in umbilical artery strips isolated from both groups. E-max values of formoterol and BRL 37344 (for normotensive pregnant women: 87.33 +/- 0.87 and 53.25 +/- 1.17 vs. for pre-eclampsia: 73.68 +/- 1.58 and 43.64 +/- 1.19, n=12, P > 0.05, respectively) were significantly smaller in strips from pre-eclamptic women (P < 0.05), with no significant change in pD(2) values. E-max values of formoterol were significantly higher than those of BRL 37344 in both tissue (P < 0.05). ICI 118.551 and SR 59230A, but not metoprolol, antagonized the relaxant effects of formoterol and of BRL 2,7344 on umbilical artery strips isolated from normotensive and pre-eclamptic pregnant women. Formoterol and BRL 37344 increased cAMP levels in both groups, but less significant in pre-eclamptic strips (P < 0.05). These results suggest that the relaxation caused in human umbilical arteries by formoterol and BRL 37344 is mediated by a mixed population of beta(2)- and beta(3)-adrenoccptor subtypes, with contribution of cAMP. Umbilical arteries from subjects with pre-eclampsia showed a weaker beta(2)- and beta(3)-receptor-mediated relaxation to formoterol and BRL 37344, suggesting that the reduced action of formoterol and BRL 37344 may be partly due to a decreased effect of cAMP. (c) 2007 Elsevier Inc. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.isversionof10.1016/j.vph.2006.12.002en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpre-eclampsiaen_US
dc.subjectformoterolen_US
dc.subjectBRL 37344en_US
dc.subjectcAMPen_US
dc.titleEffects of formoterol and BRL 37344 on human umbilical arteries in vitro in normotensive and pre-eclamptic pregnancyen_US
dc.typearticleen_US
dc.relation.journalVASCULAR PHARMACOLOGYen_US
dc.contributor.departmentAtaturk Training & Res Hosp, Dept Pharmacol, TR-35360 Izmir, Turkey -- Univ Sivas, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- Univ Sivas, Dept Obstet, Sch Med, TR-58140 Sivas, Turkey -- Univ Sivas, Dept Gynecol, Sch Med, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Physiol, TR-58140 Sivas, Turkeyen_US
dc.identifier.volume46en_US
dc.identifier.issue5en_US
dc.identifier.endpage366en_US
dc.identifier.startpage360en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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