dc.contributor.author | Pinarbasi, Ergun | |
dc.contributor.author | Percin, Ferda E. | |
dc.contributor.author | Yilmaz, Meral | |
dc.contributor.author | Akgun, Egemen | |
dc.contributor.author | Cetin, Meral | |
dc.contributor.author | Cetin, Ali | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:17:02Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:17:02Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 1341-8076 | |
dc.identifier.issn | 1447-0756 | |
dc.identifier.uri | https://dx.doi.org/10.1111/j.1447-0756.2007.00473.x | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/10668 | |
dc.description | WOS: 000243023200004 | en_US |
dc.description | PubMed ID: 17212663 | en_US |
dc.description.abstract | Aim: To assess the association between human epoxide hydrolase exon 3 and 4 polymorphisms and pre-eclampsia by carrying out a case-control study in Turkish women. Methods: DNA was extracted from peripheral blood leukocytes, and genotype distribution of exon 3 and exon 4 of epoxide hydrolase gene (EPHX) was carried out in 271 patients and 155 controls. Results: There was no statistically significant difference in the distribution of genotypes between pre-eclampsia without HELLP and pre-eclampsia plus HELLP cases and controls for the exon 3 and 4 polymorphism of EPHX. However, we found a significant association between the predicted enzyme activity level and pre-eclampsia (P = 0.018). The distribution of subjects with predicted high, intermediate and low microsomal epoxide hydrolase enzyme (EPHX) activity were 23.2, 38.8 and 38% in cases and 12, 47.3 and 40.7% in controls, respectively. Conclusion: Although we could not find any association between genetic variability in exon 3 and 4 of EPHX and pre-eclampsia, genetic variability in these two exons jointly modifies the predicted enzyme activity and may be a risk factor for pre-eclampsia. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | WILEY | en_US |
dc.relation.isversionof | 10.1111/j.1447-0756.2007.00473.x | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | genetic | en_US |
dc.subject | microsomal epoxide hydrolase | en_US |
dc.subject | polymorphism | en_US |
dc.subject | pre-eclampsia | en_US |
dc.title | Association of microsomal epoxide hydrolase gene polymorphism and pre-eclampsia in Turkish women | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | en_US |
dc.contributor.department | Cumhuriyet Univ, Fac Med, Dept Med Biol, Sch Med, TR-58140 Sivas, Turkey -- Gazi Univ, Sch Med, Dept Med Genet, Ankara, Turkey -- Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, Sivas, Turkey | en_US |
dc.contributor.authorID | Cetin, Ali -- 0000-0002-5767-7894; Percin, Ferda -- 0000-0001-9317-8155 | en_US |
dc.identifier.volume | 33 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 37 | en_US |
dc.identifier.startpage | 32 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |