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dc.contributor.authorHizmetli, Sami
dc.contributor.authorKisa, Mustafa
dc.contributor.authorGokalp, Nurdagul
dc.contributor.authorBakici, M. Zahir
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:17:04Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:17:04Z
dc.date.issued2007
dc.identifier.issn0172-8172
dc.identifier.urihttps://dx.doi.org/10.1007/s00296-006-0264-7
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10674
dc.descriptionWOS: 000243467600004en_US
dc.descriptionPubMed ID: 17102942en_US
dc.description.abstractLeptin is an adypocyte derivated peptide hormone that plays a major role in preventing obesity development by the effects at the hypothalamic level. In our study leptin levels of 41 rheumatoid arthritis (RA) patients and 25 healthy subjects as control group were assessed. Synovial fluid from 21 RA patients were collected to detect leptin levels. Synovial fluid and plasma leptin levels were analysed and correlated with RA duration, ESR, CRP, X ray changes (erosive or non-erosive disease) and negative or positive test for rheumatoid factor. There wasn't any significant difference at plasma leptin levels between RA patients (3.91 +/- 6.15) and control group (4.94 +/- 6.44) (p > 0.05). Plasma leptin levels were correlated with body mass index (BMI) in both healthy subjects and RA patients (r = 0.37; p = 0.018). Therefore in RA patients, plasma and synovial fluid leptin levels were not correlated with disease duration, ESR, CRP, negative or positive test for rheumatoid factor and erosive or non-erosive disease (p > 0.05). In conclusion leptin is correlated with BMI both in RA patients and healthy individuals but no considerable relation with disease activity.en_US
dc.language.isoengen_US
dc.publisherSPRINGERen_US
dc.relation.isversionof10.1007/s00296-006-0264-7en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectrheumatoid arthritisen_US
dc.subjectbody mass indexen_US
dc.subjectdisease activityen_US
dc.subjectleptinen_US
dc.titleAre plasma and synovial fluid leptin levels correlated with disease activity in rheumatoid arthritis ?en_US
dc.typearticleen_US
dc.relation.journalRHEUMATOLOGY INTERNATIONALen_US
dc.contributor.departmentCumhuriyet Univ, Sch Med, Dept Phys Med & Rehabil, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Microbiol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Clin Microbiol, TR-58140 Sivas, Turkeyen_US
dc.identifier.volume27en_US
dc.identifier.issue4en_US
dc.identifier.endpage338en_US
dc.identifier.startpage335en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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