Show simple item record

dc.contributor.authorYalta, Kenan
dc.contributor.authorYilmaz, Ahmet
dc.contributor.authorTurgut, Okan Onur
dc.contributor.authorErselcan, Taner
dc.contributor.authorYilmaz, Mehmet Birhan
dc.contributor.authorKaradas, Filiz
dc.contributor.authorYontar, Can
dc.contributor.authorTandogan, Izzet
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:17:43Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:17:43Z
dc.date.issued2006
dc.identifier.issn0741-238X
dc.identifier.urihttps://dx.doi.org/10.1007/BF02850225
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10759
dc.descriptionWOS: 000244518100022en_US
dc.descriptionPubMed ID: 17276972en_US
dc.description.abstractSerum carbohydrate antigen (CA-125) and carcinoembryonic antigen (CEA) have always been of clinical importance in the diagnosis and follow-up of various tumors. This study was devised to investigate the relationship between these tumor markers and acute myocardial infarction (MI). Seventy consecutive cases (59 male patients with a diagnosis of acute ST segment elevation MI and 11 male patients with a diagnosis of non-ST segment elevation Ml; mean age, 57 +/- 8.2 y) were admitted to the University Medical Center and were included in this study as "the patient group." All patients in the patient group underwent transthoracic echocardiographic examination on the third day of hospitalization. On the basis of echocardiographic findings, these 70 patients were grouped according to left ventricular ejection fraction (EF) values; EF < 55% (group 1) (n=40) and EF >= 55% (group 2) (n=30). Other parameters, including systolic pulmonary artery pressure (sPAP) and mean pulmonary artery pressure (mPAP), were also measured on transthoracic echocardiography. Serial blood samples (for follow-up of myocardial enzymes (eg, creatine kinase MB [CKMB], troponin I [Tnl], troponin T, and other routine parameters) were drawn from each patient. Serum concentrations of CEA and CA-125 measured at the 72nd hour of hospitalization and peak serum concentrations of CKMB and Tnl in the patient group were collected for comparison between subgroups (groups 1 and 2) and with "the control group," which included 30 subjects (mean age, 54 +/- 7.6 y) with no history or evidence of overt cardiac disease and with normal echocardiographic findings. The presence of any condition characterized by potential elevations in CA-125, CEA, and myocardial enzymes (CKMB, Tnl) was considered an exclusion criterion. Patients included in patient groups 1 and 2 differed significantly in terms of mean EF, mean sPAP, mean mPAP, and mean CA-125 values (P <.001 for CA-125; P <.05 for the other values). EF was found to be negatively correlated with sPAP (r=-0.692, P=.000) and mPAP (r=-0.393, P=.001). EF was also negatively correlated with CA-125 (r=-0.557, P=.000). A positive correlation was noted between CA-125 and sPAP (r=0.396, P=.001) and between CA-125 and mPAP (r=0.754, P=.000). A statistically significant difference was identified between the patient and control groups with regard to values for EF, PAP, CA-125, and myocardial enzymes (CKMB and Tnl) (P <.05 for mPAP; P <.001 for the other values). The serum concentration of CA-125, but not of CEA, may be elevated in those with acute MI compared with normal subjects. Regardless of the presence of pulmonary hypertension, elevations in CA-125 during myocardial infarction were significantly correlated with the severity of left ventricular systolic dysfunction on transthoracic echocardiography.en_US
dc.language.isoengen_US
dc.publisherHEALTH COMMUNICATIONS INCen_US
dc.relation.isversionof10.1007/BF02850225en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectserum carbohydrate antigenen_US
dc.subjectcarcinoembryonic antigenen_US
dc.subjectmyocardial infarctionen_US
dc.subjectleft ventricular systolic dysfunctionen_US
dc.titleEvaluation of tumor markers CA-125 and CEA in acute myocardial infarctionen_US
dc.typearticleen_US
dc.relation.journalADVANCES IN THERAPYen_US
dc.contributor.departmentCumhuriyet Univ, Dept Cardiol, TR-58100 Sivas, Turkey -- Cumhuriyet Univ, Dept Nucl Med, TR-58100 Sivas, Turkeyen_US
dc.contributor.authorIDTurgut, Okan -- 0000-0002-6847-3029; YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628; YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628en_US
dc.identifier.volume23en_US
dc.identifier.issue6en_US
dc.identifier.endpage1059en_US
dc.identifier.startpage1052en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record