The effects of topical ketorolac and indomethacin on measles conjunctivitis: Randomized controlled trial

Abstract

PURPOSE: To compare the effect of topical ketorolac and indomethacin on measles conjunctivitis. DESIGN: Prospective double-masked placebo-controlled randomized trial. METHODS: Sixty-two patients with severe measles conjunctivitis were included in this study. All patients were hospitalized and randomly assigned to receive ketorolac 0.5% or indomethacin 0.1% in the right eye and artificial tears in the left eye. Conjunctival hyperemia, burning sensations, foreign-body sensations, and photophobia scores were conducted at baseline and at days seven and 14. A satisfaction score was evaluated at the end of the study. 0 RESULTS: The conjunctival injection score of the con, trol eyes was significantly higher than those of the ketorolac- and indomethacin treated eyes at day seven (P < .05). The conjunctival injection score of the ketorolac-treated eyes was lower than that of the indomethacin-treated eyes at days seven and 14, but this did not reach statistical significance. There was no significant difference in the burning and foreign-body sensations and in the photophobia scores among the study eyes at baseline, day seven, and day 14 (P > .05). There was no significant difference in the satisfaction score among the study eyes at the end of the study (P > .05). CONCLUSIONS: In patients with measles during the first two weeks of infection, ketorolac and indomethacin were more effective than artificial tears in decreasing conjunctival hyperemia, but burning sensations, foreign, body sensations, and photophobia were unaffected.