dc.contributor.author | Sarac, B | |
dc.contributor.author | Yildirim, MK | |
dc.contributor.author | Bagcivan, I | |
dc.contributor.author | Kaya, K | |
dc.contributor.author | Kilicarslan, H | |
dc.contributor.author | Yildirim, S | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:21:55Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:21:55Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 0919-8172 | |
dc.identifier.issn | 1442-2042 | |
dc.identifier.uri | https://dx.doi.org/10.1111/j.1442-2042.2006.01225.x | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/10898 | |
dc.description | WOS: 000234876400011 | en_US |
dc.description | PubMed ID: 16448433 | en_US |
dc.description.abstract | Background: The incidence of hormonal dysfunction as a cause of impotence remains controversial. However, several recent studies have reported evidence of hormonal abnormalities in 25-35% of impotent men. Hypothyroidism has been reported to occur in 6% of impotent men. Methods: In the present study, we examined nitrergic responses in hypothyroidism in rabbit corpus cavernosum and compared them with controls. Results: Carbachol-induced relaxation responses and electrical field stimulation (EFS)-induced frequency-dependent relaxations decreased significantly in hypothyroid rabbits. Papaverine and sodium nitroprusside (SNP)-induced relaxation responses did not change significantly in hypothyroid rabbits. The contraction responses of phenylephrine and EFS-induced frequency-dependent contractions were significantly decreased in the hypothyroid group. Conclusions: We can speculate that the reduction of relaxant responses to EFS and carbachol in hypothyroid rabbits can depend on a decreased release of nitric oxide (NO) from nitrergic nerves and endothelium or a reduction of muscarinic receptor density. Also, decreases in contraction responses may depend on diminished adrenoceptor density. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | WILEY | en_US |
dc.relation.isversionof | 10.1111/j.1442-2042.2006.01225.x | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | carbachol | en_US |
dc.subject | electrical field stimulation | en_US |
dc.subject | hypothyroidism | en_US |
dc.subject | impotence | en_US |
dc.title | Effect of hypothyroidism on the nitrergic relaxant responses of corpus cavernosal smooth muscle in rabbits | en_US |
dc.type | article | en_US |
dc.relation.journal | INTERNATIONAL JOURNAL OF UROLOGY | en_US |
dc.contributor.department | Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Urol, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 13 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 63 | en_US |
dc.identifier.startpage | 58 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |