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dc.contributor.authorSarac, B
dc.contributor.authorYildirim, MK
dc.contributor.authorBagcivan, I
dc.contributor.authorKaya, K
dc.contributor.authorKilicarslan, H
dc.contributor.authorYildirim, S
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:21:55Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:21:55Z
dc.date.issued2006
dc.identifier.issn0919-8172
dc.identifier.issn1442-2042
dc.identifier.urihttps://dx.doi.org/10.1111/j.1442-2042.2006.01225.x
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10898
dc.descriptionWOS: 000234876400011en_US
dc.descriptionPubMed ID: 16448433en_US
dc.description.abstractBackground: The incidence of hormonal dysfunction as a cause of impotence remains controversial. However, several recent studies have reported evidence of hormonal abnormalities in 25-35% of impotent men. Hypothyroidism has been reported to occur in 6% of impotent men. Methods: In the present study, we examined nitrergic responses in hypothyroidism in rabbit corpus cavernosum and compared them with controls. Results: Carbachol-induced relaxation responses and electrical field stimulation (EFS)-induced frequency-dependent relaxations decreased significantly in hypothyroid rabbits. Papaverine and sodium nitroprusside (SNP)-induced relaxation responses did not change significantly in hypothyroid rabbits. The contraction responses of phenylephrine and EFS-induced frequency-dependent contractions were significantly decreased in the hypothyroid group. Conclusions: We can speculate that the reduction of relaxant responses to EFS and carbachol in hypothyroid rabbits can depend on a decreased release of nitric oxide (NO) from nitrergic nerves and endothelium or a reduction of muscarinic receptor density. Also, decreases in contraction responses may depend on diminished adrenoceptor density.en_US
dc.language.isoengen_US
dc.publisherWILEYen_US
dc.relation.isversionof10.1111/j.1442-2042.2006.01225.xen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcarbacholen_US
dc.subjectelectrical field stimulationen_US
dc.subjecthypothyroidismen_US
dc.subjectimpotenceen_US
dc.titleEffect of hypothyroidism on the nitrergic relaxant responses of corpus cavernosal smooth muscle in rabbitsen_US
dc.typearticleen_US
dc.relation.journalINTERNATIONAL JOURNAL OF UROLOGYen_US
dc.contributor.departmentCumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Urol, TR-58140 Sivas, Turkeyen_US
dc.identifier.volume13en_US
dc.identifier.issue1en_US
dc.identifier.endpage63en_US
dc.identifier.startpage58en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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