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dc.contributor.authorOzec, Y
dc.contributor.authorOzturk, M
dc.contributor.authorKylyc, E
dc.contributor.authorYeler, H
dc.contributor.authorGoze, F
dc.contributor.authorGumus, C
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:21:56Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:21:56Z
dc.date.issued2006
dc.identifier.issn1049-2275
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10903
dc.descriptionWOS: 000235065900017en_US
dc.descriptionPubMed ID: 16432412en_US
dc.description.abstractThe purpose of this investigation was to study the effects of recombinant human bone morphogenetic protein-2 (rhBMP-2) on bone formation of mandibular distraction osteogenesis. Six skeletally mature sheep underwent 10 mm of bilateral mandibular distraction osteogenesis via a custom-made distractor. Three micrograms of rhBMP-2 with a collagen carrier was implanted in the osteotomy site of one side of the mandible during the osteotomy phase. The contralateral side was used as the control group, and no material was implanted into the distracted area. At 10 days after the end of distraction, all animals were killed, and the distracted calluses were harvested for radiologic and histologic analysis. New bone was generated in the distracted zone in all groups. Histologic and radiologic examination showed that the new bone formation was greater in the rhBMP-2 group than in the control group. Quantitative computed tomography evaluation, however, did not demonstrate a significantly different mean bone density of the regenerates between the 2 groups. The results indicate that application of a rhBMP-2/collagen implant during the osteotomy phase of distraction osteogenesis increased bone formation but did not have a significant effect on bone density of the regenerates.en_US
dc.language.isoengen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdistraction osteogenesisen_US
dc.subjectrecombinant human bone morphogenetic protein-2en_US
dc.subjectmandibular lengtheningen_US
dc.subjectsheepen_US
dc.titleEffect of recombinant human bone morphogenetic protein-2 on mandibular distraction osteogenesisen_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF CRANIOFACIAL SURGERYen_US
dc.contributor.departmentCumhuriyet Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Sivas, Turkey -- Gazi Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Ankara, Turkey -- Cumhuriyet Univ, Sch Med, Dept Pathol, Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Radiol, Sivas, Turkeyen_US
dc.identifier.volume17en_US
dc.identifier.issue1en_US
dc.identifier.endpage83en_US
dc.identifier.startpage80en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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