dc.contributor.author | Bagcivan, Ihsan | |
dc.contributor.author | Kaya, Tijen | |
dc.contributor.author | Turan, Mustafa | |
dc.contributor.author | Karadas, Baris | |
dc.contributor.author | Sarac, Buelent | |
dc.contributor.author | Duman, Mustafa | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:21:57Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:21:57Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 1424-3903 | |
dc.identifier.uri | https://dx.doi.org/10.1159/000091959 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/10916 | |
dc.description | WOS: 000244257000010 | en_US |
dc.description | PubMed ID: 16534245 | en_US |
dc.description.abstract | Background/Aims: Nitric oxide (NO) is a major inhibitor in various parts of the gastrointestinal tract. This study was designed to compare the effects of YC-1, NO-independent soluble guanylate cyclase (sGC) activator, and DEA/NO, NO-nucleophile adduct, on sheep sphincters of Oddi (SO). Methods: SO rings were mounted in a tissue bath and tested for changes in isometric tension in response to 3-(5'-hydroxymethyl- 2'-furyl)-1-benzylindazole (YC-1, 10(-10)-10(-5) M), diethylamine/NO complex (DEA/NO, 10(-8)-10(-4) M). We also evaluated the effect of YC-1 (10(-6) and 10(-5) M) and DEA/NO (10(-5) and 10(-4) M) on the levels cyclic GMP (cGMP) in isolated SO. Results: YC-1 (10(-10)-10(-5) M) and DEA/NO (10(-8)-10(-4) M) induced concentration-dependent relaxation of isolated SO rings precontracted with carbachol (10(-6) M). The pEC(50) value of DEA/NO was significantly lower than those for YC-1 (p < 0.05), with no change of E-max values. YC-1 increased cGMP levels more than control, carbachol and DEA/NO groups (p < 0.05). Conclusion: These results show that YC-1 is a more potent relaxant than DEA/NO and causes more elevation of cGMP levels in isolated SO rings. Copyright (C) 2006 S. Karger AG, Basel and IAP. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | KARGER | en_US |
dc.relation.isversionof | 10.1159/000091959 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | sphincter of Oddi | en_US |
dc.subject | relaxation | en_US |
dc.subject | YC-1 | en_US |
dc.subject | DEA/NO | en_US |
dc.title | Comparative relaxant effects of YC-1 and DEA/NO on the sheep sphincter of Oddi | en_US |
dc.type | article | en_US |
dc.relation.journal | PANCREATOLOGY | en_US |
dc.contributor.department | Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Surg, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.endpage | 219 | en_US |
dc.identifier.startpage | 215 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |