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dc.contributor.authorTutar, Yusuf
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:21:58Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:21:58Z
dc.date.issued2006
dc.identifier.issn0929-8665
dc.identifier.issn1875-5305
dc.identifier.urihttps://dx.doi.org/10.2174/092986606777790593
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10923
dc.descriptionWOS: 000238786500009en_US
dc.descriptionPubMed ID: 17018013en_US
dc.description.abstractHsp70 is a universally conserved essential protein chaperone. In addition to its roles in many cellular process, Hsp70 protects cells from stress by binding partially unfolded proteins. Therefore, Hsp70 prevents protein aggregation and prion formation. Prions are infectious agents and are responsible for several fatal neurodegenerative diseases. Eukaryotic cells have several cytosolic Hsp70 isoforms, some constitutively expressed (Hsc70s), and others expressed only when cells are exposed to stress (Hsp705). To determine which factors conferred functional specificity, we constructed hybrid Hsc/Hsp chaperones. All hybrids supported growth except those that contained the ATPase domain derived from inducible Hsp70. Thus, regulation of peptide binding by ATP hydrolysis must differ significantly between Hsc- and Hsp70 isoforms. In this work, nucleotide and peptide binding domain communication of Hsp70 proteins during their interaction with nucleotides and peptide substrates were investigated in vitro by using hybrid constructs.en_US
dc.language.isoengen_US
dc.publisherBENTHAM SCIENCE PUBL LTDen_US
dc.relation.isversionof10.2174/092986606777790593en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHsp (Heat shock protein)en_US
dc.subjectco-chaperon (Hsp40en_US
dc.subjectYdj1 and Sis1).en_US
dc.titleHeat shock proteins, substrate specificity and modulation of functionen_US
dc.typearticleen_US
dc.relation.journalPROTEIN AND PEPTIDE LETTERSen_US
dc.contributor.departmentCumhuriyet Univ, Dept Chem, Fac Sci, TR-58140 Sivas, Turkeyen_US
dc.identifier.volume13en_US
dc.identifier.issue7en_US
dc.identifier.endpage705en_US
dc.identifier.startpage699en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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