Early effect of exogenous Na hyaluronate on mucociliary clearance

Abstract

Background: An animal study is performed to determine the early effect of 1% Na hyaluronate on mucociliary clearance function. Methods: One percent of Na hyaluronate was introduced into the maxillary sinuses of rabbits by anterior antrostomy. A physiological solution of 1% NaCl was introduced into the maxillary sinuses of a control group to equalize the influence of Na for both groups. The treatment material was sprayed with an atomizer for coating the maxillary sinus lining. Technetium-99m diethylenetriamine pentaacetate dynamic scintigraphic imaging was performed to evaluate mucociliary clearance function on all rabbits 72 hours after the surgical procedure. Results: Although the mean rate of mucociliary clearance of the Na hyaluronate group was slightly worse than the control group; there was no statistically significant difference between them. Conclusion: There is no early effect of exogenous 1% Na hyaluronate on mucociliary clearance function.