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dc.contributor.authorKaradag, O
dc.contributor.authorEroglu, E
dc.contributor.authorGurelik, M
dc.contributor.authorGoksel, HM
dc.contributor.authorKilic, E
dc.contributor.authorGulturk, S
dc.descriptionWOS: 000226370100023en_US
dc.descriptionPubMed ID: 15565484en_US
dc.description.abstractBackground. Cerebral microcirculatory changes during cerebral vasospasm after aneurysmal subarachnoid haemorrhage (SAH) are still controversial and uncertain. The aim of our study is to demonstrate that spinal cord stimulation (SCS) augments cerebral cortical microcirculatory blood flow in an experimental cerebral vasospasm model by using Laser Doppler Flowmetry (LDF). Method. The experiments were carried out on 24 New Zealand rabbits. Three experimental groups were designed. In group 1, Cerebral cortical blood flow (CCoBF) was evaluated by LDF in 8 rabbits. In group 2, Intracisternal saline injection and cervical epidural electrode placement without SCS were performed in 8 animals before LDF In group 3, LDF was performed before and after SCS on the 4(th) day of SAH in 8 rabbits. CCoBF parameters obtained from LDF data were compared. Findings. The occurrence of vasospasm after SAH was demonstrated with significant changes in LDF values. In all SAH animals, SCS resulted in significant increase (approximate to30%) in CCoBF. This increase was observed to continue even after the cessation stimulation. Conclusions. These results indicate that SCS improves cortical ischemia due to vasospasm after induced SAH. The cervical SCS may constitute a new therapeutic modality in treating disturbed CCoBF due to vasospasm.en_US
dc.publisherSPRINGER WIENen_US
dc.subjectCerebral cortical blood flowen_US
dc.subjectcerebral vasospasmen_US
dc.subjectLaser Doppler Flowmetryen_US
dc.subjectspinal cord stimulationen_US
dc.titleCervical spinal cord stimulation increases cerebral cortical blood flow in an experimental cerebral vasospasm modelen_US
dc.relation.journalACTA NEUROCHIRURGICAen_US
dc.contributor.departmentCumhuriyet Univ Hastanesi, Dept Neurosurg, Beyin Sinir Cerrahisi ABD, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Fac Dent, Dept Oral & Maxillofacial Surg, Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Physiol, Sivas, Turkeyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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