Show simple item record

dc.contributor.authorElaldi, N
dc.contributor.authorSoydan, S
dc.contributor.authorTuran, M
dc.contributor.authorDuman, M
dc.contributor.authorGoktas, S
dc.contributor.authorTopcu, O
dc.contributor.authorKarakus, G
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:22:18Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:22:18Z
dc.date.issued2005
dc.identifier.issn0177-9990
dc.identifier.urihttps://dx.doi.org/10.1159/000086941
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11073
dc.descriptionWOS: 000232291100013en_US
dc.description.abstractBackground: The biliary secretion of antibiotics decreases proportionately to an increase in intrabiliary pressure. The aim of this study was to evaluate the effect of bile duct obstruction on biliary secretion of meropenem. Material and Methods: 110 Wistar albino rats were used in this study. There were 11 groups each including 10 rats. In groups A1, B1, C1, D1, E1 and F, the common bile ducts were ligated for 7 days. In the control groups (A2, B2, C2, D2 and E2), sham surgery was performed. A single dose of 14 mg/kg of meropenem was infused intravenously for 10 min. The serum concentration of meropenem was measured 30 min later in groups A1 and A2, 1 h later in groups B1 and B2, 2 h later in groups C1 and C2, 4 h later in groups D1 and D2 and 6 h later in groups E1 and E2. In group F, the intrabiliary pressure was measured in situ on day 7 for confirmation. Results: The biliary / serum level ratio of meropenem in the obstructed rats within 30 min, 1, 2, 4 and 6 h of infusion was 163, 113, 67, 36 and 28%, respectively. The biliary/serum level ratio of meropenem in the control rats within 30 min, 1, 2, 4 and 6 h of infusion were 302, 149, 123, 127 and 126%, respectively. Conclusion: Compared to the control rats, the biliary levels of meropenem was reduced in the obstructed rats compared to control rats. However, the measured levels were greater than the minimum inhibitory concentration (MIC). After conduction of clinical studies, meropenem may be an ideal agent in the treatment of acute cholecystitis and cholangitis caused by obstruction of the biliary tract.en_US
dc.language.isodeuen_US
dc.publisherKARGERen_US
dc.relation.isversionof10.1159/000086941en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectobstructive jaundiceen_US
dc.subjectmeropenemen_US
dc.subjectbiliary secretionen_US
dc.titleEffect of bile duct obstruction on the biliary secretion of meropenem in ratsen_US
dc.typearticleen_US
dc.relation.journalCHIRURGISCHE GASTROENTEROLOGIEen_US
dc.contributor.departmentCumhuriyet Univ, Fac Med, Dept Clin Bacteriol & Infect Dis, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Fac Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Fac Med, Dept Gen Surg, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Fac Med, Res Labs, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDKARAKUS, Gulderen -- 0000-0003-2596-9208; Elaldi, Nazif -- 0000-0002-9515-770Xen_US
dc.identifier.volume21en_US
dc.identifier.issue3en_US
dc.identifier.endpage284en_US
dc.identifier.startpage280en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record