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dc.contributor.authorOzdemir, I
dc.contributor.authorUstundag, N
dc.contributor.authorGuven, A
dc.contributor.authorDuran, B
dc.contributor.authorDemirci, F
dc.descriptionWOS: 000233038900001en_US
dc.descriptionPubMed ID: 16020932en_US
dc.description.abstractObjective: To examine the effect of clomiphene citrate ( CC) on the ovarian, endometrial, and cervical histologies in a rat model. Methods: The rats (n = 40) were randomly assigned to 4 treatment groups: CC 50 ( repetitive doses of 0.2 mg CC); CC 100 ( repetitive doses of 0.4 mg CC); CC 200 ( repetitive doses of 0.8 mg CC), and control ( repetitive doses of normal saline). Each study group received its CC dose intraperitoneally in 2 ml saline for 5 days and the controls received 2 ml saline only. Each treatment cycle was repeated six times. Six months later the rats were euthanized. Their ovaries, uterine horns, and cervices were removed and examined for histologic changes. Results: We found no significant difference in the number of follicles and corpora lutea of the study groups ( p >0.05). The numbers of granulosa, theca, and luteal cells of the CC 100 and CC 200 groups were significantly higher than those of the CC 50 group and controls ( p < 0.05). There was no important finding related to pre-malign and malign changes in ovarian, endometrial and cervical samples of the control and CC 50 groups. Focal atypia and atypical mitoses were noted in 2 cases of granulosa cells in the CC 100 and CC 200 groups. Conclusion: We did not find an association between the use of CC and ovarian, endometrial, and cervical neoplasms; nevertheless, we noticed an increase in granulosa, theca and luteal cells with high doses of CC, which may be a risk factor for granulosa, theca, and luteal cell tumors. Copyright (C) 2005 S. Karger AG, Basel.en_US
dc.subjectclomiphene citrateen_US
dc.subjectendometrial histologyen_US
dc.subjectovarian histologyen_US
dc.subjectrat modelen_US
dc.titleEffect of clomiphene citrate on ovarian, endometrial, and cervical histologies in a rat modelen_US
dc.contributor.departmentAbant Izzet Baysal Univ, Duzce Sch Med, Dept Obstet & Gynecol, TR-81620 Konuralp, Duczce, Turkey -- Abant Izzet Baysal Univ, Duzce Sch Med, Dept Pathol, TR-81620 Konuralp, Duczce, Turkey -- Abant Izzet Baysal Univ, Duzce Sch Med, Dept Histol & Embryol, TR-81620 Konuralp, Duczce, Turkey -- Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, Sivas, Turkeyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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