dc.contributor.author | Kaya, M | |
dc.contributor.author | Gulturk, S | |
dc.contributor.author | Elmas, L | |
dc.contributor.author | Kalayci, R | |
dc.contributor.author | Arican, N | |
dc.contributor.author | Kocyildiz, ZC | |
dc.contributor.author | Kucuk, M | |
dc.contributor.author | Yorulmaz, H | |
dc.contributor.author | Sivas, A | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:22:29Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:22:29Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0024-3205 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.lfs.2004.07.012 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11133 | |
dc.description | WOS: 000225008900007 | en_US |
dc.description | PubMed ID: 15519365 | en_US |
dc.description.abstract | The study was performed to evaluate whether magnesium sulfate could alter the degree of disruption of the blood-brain barrier (BBB) caused by hyperosmotic mannitol. Wistar adult female rats were infused with 25% mannitol into the left internal carotid artery. Each animal received intraperitoneally a 300 mg/kg loading dose of magnesium sulfate, dissolved in 0.9% saline, followed by a further 100 mg/kg dose. In the other group, intracarotid infusion of magnesium sulfate was performed at a dose of 150 mg/kg 10 min before mannitol administration. Evans blue (EB) dye was used as a marker of BBB disruption. The measured serum glucose and magnesium levels increased after mannitol and/or magnesium administration when compared with their initial values before treatment (P < 0.01). Water content of the left hemisphere was significantly increased by hyperosmotic mannitol (P < 0.01). The increased water content in the mannitol-perfused hemisphere was significantly decreased by magnesium treatment (P < 0.05). The content of EB dye in the mannitol-perfused hemisphere markedly increased when compared with the right hemisphere of the same brain (P < 0.01). The EB dye content in the mannitol-perfused hemisphere following both intraperitoneal and intraarterial administration of magnesium decreased when compared with mannitol alone (P < 0.01). We conclude that although magnesium sulfate administration by both intracarotid arterial and intraperitoneal routes attenuates BBB disruption caused by hyperosmolar mannitol, particularly intraperitoneal route of magnesium sulfate administration may provide a useful strategy to limit the transient osmotic opening of the BBB. (C) 2004 Elsevier Inc. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.relation.isversionof | 10.1016/j.lfs.2004.07.012 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | hyperosmotic mannitol | en_US |
dc.subject | magnesium | en_US |
dc.subject | blood-brain barrier | en_US |
dc.subject | Evans blue | en_US |
dc.subject | brain water | en_US |
dc.title | The effects of magnesium sulfate on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats | en_US |
dc.type | article | en_US |
dc.relation.journal | LIFE SCIENCES | en_US |
dc.contributor.department | Univ Istanbul, Dept Physiol, Istanbul Fac Med, TR-34390 Istanbul, Turkey -- Cumhuriyet Univ, Fac Med, Dept Physiol, Sivas, Turkey -- Univ Istanbul, Dept Forens Med, Istanbul Fac Med, TR-34390 Istanbul, Turkey -- Univ Istanbul, Expt Med Res Inst, TR-34390 Istanbul, Turkey -- Univ Istanbul, Istanbul Fac Med, Dept Biochem, TR-34390 Istanbul, Turkey | en_US |
dc.contributor.authorID | ARICAN, Nadir -- 0000-0002-9736-0277; Kalayci, Rivaze -- 0000-0002-7061-4863 | en_US |
dc.identifier.volume | 76 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 212 | en_US |
dc.identifier.startpage | 201 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |