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dc.contributor.authorAdiguzel, O
dc.contributor.authorKaptanoglu, E
dc.contributor.authorTurgut, B
dc.contributor.authorNacitarhan, V
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:22:42Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:22:42Z
dc.date.issued2004
dc.identifier.issn0038-4348
dc.identifier.issn1541-8243
dc.identifier.urihttps://dx.doi.org/10.1097/00007611-200407000-00008
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11194
dc.descriptionWOS: 000222806400008en_US
dc.descriptionPubMed ID: 15301122en_US
dc.description.abstractobjectives: Regional deficits in cerebral blood flow have been reported in a few studies of fibromyalgia; however, there is no information on the effects of treatment and clinical recovery on these abnormalities. We evaluated the effects of amitriptyline treatment and consequent clinical recovery on cerebral blood flow changes in fibromyalgia. Methods: We assessed cerebral blood flow with a semiquantitative functional brain mapping technique of single-photon emission computed tomography in 14 patients with primary fibromyalgia before and after 3 months of amitriptyline treatment. Patients were followed by visual analog scale, tender point count, and Beek Depression Inventory for clinical improvement. Results: There was statistically significant improvement in visual analog scale and tender point count after treatment. Beck Depression Inventory did not change significantly. Statistically significant blood flow increase in bilateral hemithalami and basal ganglia and decrease in bilateral temporal, left temporo-occipital, and right occipital lobes were observed on single-photon emission computed tomography after treatment. Conclusions: We speculate that these findings could indicate that deficits in cerebral blood flow in fibromyalgia improve parallel to clinical recovery.en_US
dc.language.isoengen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.isversionof10.1097/00007611-200407000-00008en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectamitriptylineen_US
dc.subjectcerebral blood flowen_US
dc.subjectfibromyalgiaen_US
dc.subjectSPECTen_US
dc.titleThe possible effect of clinical recovery regional cerebral blood flow deficits in fibromyalgia: A prospective study with semiquantitative SPECTen_US
dc.typearticleen_US
dc.relation.journalSOUTHERN MEDICAL JOURNALen_US
dc.contributor.departmentCumhuriyet Univ, Dept Rheumatol, Sivas, Turkey -- Cumhuriyet Univ, Dept Nucl Med, Sivas, Turkeyen_US
dc.contributor.authorIDNacitarhan, Vedat -- 0000-0003-1756-8615en_US
dc.identifier.volume97en_US
dc.identifier.issue7en_US
dc.identifier.endpage655en_US
dc.identifier.startpage651en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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