dc.contributor.author | Berkan, O | |
dc.contributor.author | Gol, MK | |
dc.contributor.author | Icagasioglu, S | |
dc.contributor.author | Cetinkaya, O | |
dc.contributor.author | Yildiz, E | |
dc.contributor.author | Dogan, K | |
dc.contributor.author | Gunay, I | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:22:47Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:22:47Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 1078-5884 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.ejvs.2004.02.006 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11217 | |
dc.description | WOS: 000221169000018 | en_US |
dc.description | PubMed ID: 15079783 | en_US |
dc.description.abstract | Objective. This study tests whether sialic acid is a mediator of the lung injury following lower extremity ischemia/reperfusion (I/R). Design. Prospective randomised study. Materials and Methods. Thirty-one Sprague-Dawley rats were randomised into four groups: group 1, aorta was exposed but not clamped; group 2, aorta clamped for 3 h, followed by 1 h of reperfusion; group 3, 50 mg/kg pentoxifylline administrated before the aorta was clamped; and group 4, 1 mg/kg dexametasone administrated before the aorta was clamped. Serial arterial blood samples for blood gas, tumor necrosis factor-alpha (TNF-alpha), and total SA (TSA) assay were obtained. The lungs were removed and histologically examined for evidence of injury. Results. Groups 2, 3, and 4 had significantly higher peak serum TSA concentrations compared with groups 1 (group I vs. 2, p = 0.001; group 1 vs. 3, p = 0.002; group 1 vs. 4, p = 0.001). Group 3 had lower peak serum TSA concentration, Groups 2 and 4 had significantly higher peak serum TNF-alpha concentrations (p = 0.0001) compared with groups 1 and 3. Group 3 had lower peak serum TNF-alpha concentration. Lower TSA and TNF-alpha levels are associated with lesser degrees of lung injury. Conclusions. TSA and TNF appear during events that lead to lung injury following lower extremity I/R. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | W B SAUNDERS CO LTD | en_US |
dc.relation.isversionof | 10.1016/j.ejvs.2004.02.006 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | sialic acid | en_US |
dc.subject | tumor necrosis factor-alpha | en_US |
dc.subject | torso ischemia and reperfusion | en_US |
dc.subject | lung injury | en_US |
dc.title | Sialic acid is a marker of lung injury following lower extremities ischemia/reperfusion | en_US |
dc.type | article | en_US |
dc.relation.journal | EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY | en_US |
dc.contributor.department | Cumhuriyet Univ, Fac Med, Cardiovasc Surg Clin, Dept Cardiovasc Surg, Sivas, Turkey -- Cumhuriyet Univ, Fac Med, Dept Surg, Sivas, Turkey -- Cumhuriyet Univ, Fac Med, Dept Biochem, Sivas, Turkey -- Cumhuriyet Univ, Fac Med, Dept Pathol, Sivas, Turkey -- Turkiye Yuksek Ihtisas Hosp, Cardiovasc Surg Clin, Ankara, Turkey | en_US |
dc.identifier.volume | 27 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | 558 | en_US |
dc.identifier.startpage | 553 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |