dc.contributor.author | Canbay, E | |
dc.contributor.author | Degerli, N | |
dc.contributor.author | Gulluoglu, BM | |
dc.contributor.author | Kaya, H | |
dc.contributor.author | Sen, MT | |
dc.contributor.author | Bardakci, F | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:22:51Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:22:51Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0300-7995 | |
dc.identifier.uri | https://dx.doi.org/10.1185/030079904125003232 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11237 | |
dc.description | WOS: 000220994200014 | en_US |
dc.description | PubMed ID: 15119991 | en_US |
dc.description.abstract | Objective: Constitutive activation of various hormone and growth factor receptors is newly recognised as a common cause of tumour development. This study investigated the presence of any mutation or polymorphism of prolactin receptor (PRLR) in 38 patients with breast cancer. Research methods: Genomic DNA was extracted and PCR amplification was carried out for exon 1-10 of PRLR from tumoral and adjacent non-cancerous breast tissue of tumour specimens from 38 breast cancer patients. PCR products were analysed by SSCP and automatic sequencing for mutations. Results: For the first time, A150C (Leu-->Ile) transversion at exon 6 of PRLR in tumour tissues, in adjacent non-cancerous breast tissues, and in blood samples of two (5.3%) out of 38 patients with breast cancer were detected. In contrast to this finding, no polymorphism of PRLR in blood samples of 100 normal individuals were found. Conclusion: Polymorphism of prolactin receptors might play a role in mammary carcinogenesis as a consequence of intracellular changes of PRLR signalling. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | LIBRAPHARM | en_US |
dc.relation.isversionof | 10.1185/030079904125003232 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | breast cancer | en_US |
dc.subject | gene polymorphism | en_US |
dc.subject | mammary carcinogenesis | en_US |
dc.subject | prolactin receptors | en_US |
dc.subject | receptors | en_US |
dc.title | Could prolactin receptor gene polymorphism play a role in pathogenesis of breast carcinoma? | en_US |
dc.type | article | en_US |
dc.relation.journal | CURRENT MEDICAL RESEARCH AND OPINION | en_US |
dc.contributor.department | Cumhuriyet Univ Hosp, Dept Gen Surg, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Dept Biol, Sivas, Turkey -- Marmara Univ Hosp, Dept Gen Surg, Istanbul, Turkey -- Marmara Univ Hosp, Dept Pathol, Istanbul, Turkey | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 540 | en_US |
dc.identifier.startpage | 533 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |