dc.contributor.author | Gurelik, M | |
dc.contributor.author | Bolat, M | |
dc.contributor.author | Ozturk, M | |
dc.contributor.author | Polat, S | |
dc.contributor.author | Goksel, HM | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:23:06Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:23:06Z | |
dc.date.issued | 2004 | |
dc.identifier.issn | 0893-6609 | |
dc.identifier.uri | https://dx.doi.org/10.1002/nrc.10105 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11295 | |
dc.description | WOS: 000220060200006 | en_US |
dc.description.abstract | Several different mechanisms contribute to the pathogenesis of cerebral vasospasm after subarachnoid haemorrhage. Whatever these mechanisms are, the vessel contraction is ultimately induced by an increase of free intracellular Ca2+ in the arterial wall. In this study, we investigated the effect on cerebral blood flow of a new dihydropyridine derivative Ca-channel blocker Niguldipine, in an rabbit experimental cerebral vasospasm model. The cerebral blood flow was significantly decreased in the saline treatment group when compared with control group. Niguldipine pretreatment caused a significant increase in cerebral blood flow. This effect should be investigated further. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | JOHN WILEY & SONS LTD | en_US |
dc.relation.isversionof | 10.1002/nrc.10105 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | niguldipine | en_US |
dc.subject | calcium channel antagonist | en_US |
dc.subject | cerebral vasospasm | en_US |
dc.subject | laser Doppler flowmetry | en_US |
dc.title | The effects of Niguldipine pretreatment on cerebral vasospasm after subarachnoid haemorrhage in rabbits | en_US |
dc.type | article | en_US |
dc.relation.journal | NEUROSCIENCE RESEARCH COMMUNICATIONS | en_US |
dc.contributor.department | Cumhuriyet Univ, Fac Med, Dept Neurosurg, Sivas, Turkey -- State Hosp, Dept Neurosurg, Aksaray, Turkey -- Cumhuriyet Univ, Fac Dent, Dept Oral & Maxillofacial Surg, Sivas, Turkey | en_US |
dc.contributor.authorID | Polat, Serkan -- 0000-0002-5814-5451 | en_US |
dc.identifier.volume | 34 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 55 | en_US |
dc.identifier.startpage | 47 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |