dc.contributor.author | Duran, B | |
dc.contributor.author | Ak, D | |
dc.contributor.author | Cetin, A | |
dc.contributor.author | Guvenal, T | |
dc.contributor.author | Cetin, M | |
dc.contributor.author | Imir, AG | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:23:26Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:23:26Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 1341-1357 | |
dc.identifier.uri | https://dx.doi.org/10.1538/expanim.52.267 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11369 | |
dc.description | WOS: 000184424200001 | en_US |
dc.description | PubMed ID: 14562602 | en_US |
dc.description.abstract | Background: Postsurgical adhesions can occur following virtually all types of surgery, resulting in serious clinical complications. Therefore, prevention of adhesions is an important goal of surgical practice. A rat uterine horn model was used to investigate the efficacy of NO-carboxymethylchitosan (NOCC) and spermine NONOate (SPER/NO) alone and in combination in preventing adhesion formation. Methods: Sixty Wistar albino rats underwent bilateral uterine horn injury with a unipolar cautery. Study groups were as follows: (i) control group, no adjuvant therapy; and those with adjuvant applied, (ii) normal saline group, 2 ml of normal saline was given; (iii) NOCC group, 2 ml of 2% NOCC gel was given; (iv) SPER/NO group, 2 ml of SPER/NO (0.5 mg/ml) was given, and (v) NOCC plus SPER/NO group, 2 ml of 2% NOCC gel including SPER/NO (0.5 mg/ml) was given. After 14 days, all animals were euthanatized, and a standard adhesion scoring system including extent and severity scores was applied by a blinded examiner. Results: The extent score in NOCC plus SPER/NO group was significantly lower than those of control and normal saline groups (p<0.05). The extent score in NOCC group was significantly lower than that of normal saline group (p<0.05). The extent score in NOCC plus SPER/NO group was significantly lower than that of SPER/NO group (p<0.05). The severity score was significantly lower in NOCC plus SPER/NO and NOCC groups than that of control group (p<0.05). The severity score was significantly lower in NOCC plus SPER/NO group than that of SPER/NO group (p<0.05). Conclusions: Postoperative administration of NOCC gel and SPER/NO alone and especially in combination to the site of peritoneal injury reduces the formation of adhesions in the rat uterine horn model. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | INT PRESS EDITING CENTRE INC | en_US |
dc.relation.isversionof | 10.1538/expanim.52.267 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | N,O-carboxymethylchitosan | en_US |
dc.subject | postoperative adhesion | en_US |
dc.subject | spermine NONOate | en_US |
dc.subject | uterus | en_US |
dc.subject | rat | en_US |
dc.title | Reduction of postoperative adhesions by N, O-carboxymethylchitosan and spermine NONOate in rats | en_US |
dc.type | article | en_US |
dc.relation.journal | EXPERIMENTAL ANIMALS | en_US |
dc.contributor.department | Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | Cetin, Ali -- 0000-0002-5767-7894 | en_US |
dc.identifier.volume | 52 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 272 | en_US |
dc.identifier.startpage | 267 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |