Show simple item record

dc.contributor.authorDuran, B
dc.contributor.authorAk, D
dc.contributor.authorCetin, A
dc.contributor.authorGuvenal, T
dc.contributor.authorCetin, M
dc.contributor.authorImir, AG
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:23:26Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:23:26Z
dc.date.issued2003
dc.identifier.issn1341-1357
dc.identifier.urihttps://dx.doi.org/10.1538/expanim.52.267
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11369
dc.descriptionWOS: 000184424200001en_US
dc.descriptionPubMed ID: 14562602en_US
dc.description.abstractBackground: Postsurgical adhesions can occur following virtually all types of surgery, resulting in serious clinical complications. Therefore, prevention of adhesions is an important goal of surgical practice. A rat uterine horn model was used to investigate the efficacy of NO-carboxymethylchitosan (NOCC) and spermine NONOate (SPER/NO) alone and in combination in preventing adhesion formation. Methods: Sixty Wistar albino rats underwent bilateral uterine horn injury with a unipolar cautery. Study groups were as follows: (i) control group, no adjuvant therapy; and those with adjuvant applied, (ii) normal saline group, 2 ml of normal saline was given; (iii) NOCC group, 2 ml of 2% NOCC gel was given; (iv) SPER/NO group, 2 ml of SPER/NO (0.5 mg/ml) was given, and (v) NOCC plus SPER/NO group, 2 ml of 2% NOCC gel including SPER/NO (0.5 mg/ml) was given. After 14 days, all animals were euthanatized, and a standard adhesion scoring system including extent and severity scores was applied by a blinded examiner. Results: The extent score in NOCC plus SPER/NO group was significantly lower than those of control and normal saline groups (p<0.05). The extent score in NOCC group was significantly lower than that of normal saline group (p<0.05). The extent score in NOCC plus SPER/NO group was significantly lower than that of SPER/NO group (p<0.05). The severity score was significantly lower in NOCC plus SPER/NO and NOCC groups than that of control group (p<0.05). The severity score was significantly lower in NOCC plus SPER/NO group than that of SPER/NO group (p<0.05). Conclusions: Postoperative administration of NOCC gel and SPER/NO alone and especially in combination to the site of peritoneal injury reduces the formation of adhesions in the rat uterine horn model.en_US
dc.language.isoengen_US
dc.publisherINT PRESS EDITING CENTRE INCen_US
dc.relation.isversionof10.1538/expanim.52.267en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectN,O-carboxymethylchitosanen_US
dc.subjectpostoperative adhesionen_US
dc.subjectspermine NONOateen_US
dc.subjectuterusen_US
dc.subjectraten_US
dc.titleReduction of postoperative adhesions by N, O-carboxymethylchitosan and spermine NONOate in ratsen_US
dc.typearticleen_US
dc.relation.journalEXPERIMENTAL ANIMALSen_US
dc.contributor.departmentCumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDCetin, Ali -- 0000-0002-5767-7894en_US
dc.identifier.volume52en_US
dc.identifier.issue4en_US
dc.identifier.endpage272en_US
dc.identifier.startpage267en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record