dc.contributor.author | Kaya, TJ | |
dc.contributor.author | Gursoy, SN | |
dc.contributor.author | Karadas, B | |
dc.contributor.author | Sarac, B | |
dc.contributor.author | Kafali, H | |
dc.contributor.author | Soydan, AS | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:23:32Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:23:32Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 1671-4083 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11389 | |
dc.description | WOS: 000182553500001 | en_US |
dc.description | PubMed ID: 12740170 | en_US |
dc.description.abstract | Aim: The mechanism of tramadol-induced vasodilation was investigated using isolated rabbit thoracic aortic rings. Methods: Aortic rings from 8 rabbits were placed in organ bath and precontracted with phenylephrine (10(-5) mol/L) before addition of tramadol. Relaxation responses by tramadol were evaluated in the presence and absence of endothelium, indomethacin (an inhibitor of cyclooxygenase), N(G)-nitro-L-arginine methyl ester (L-NAME, a specific inhibitor of nitric oxide synthase), glibenclamide (an inhibitor of ATP-sensitive potassium channels), tetraethylammonium chloride(TEA, an inhibitor of calcium-sensitive potassium channels), and naloxone (an antagonist of opioid receptors). Results: Tramadol (10(-4) mol/L and 3x10(-4) mol/L) caused significant vasodilation in endothelium-intact and endothelium-denuded aortic rings (P<0.05). The relaxation response to tramadol was significantly greater in endothelium-intact rings than in endothelium-denuded rings. Pretreatment of aortic rings with indomethacin (10(-5) mol/L), glibenclamide (10(-5) mol/L), TEA (10(-3) mol/L), and naloxone (10(-4) mol/L) had no effect on the tramadol-induced relaxation. In endothelium-intact rings, L-NAME (10(-4) mol/L) pretreatment caused marked inhibition of the relaxation induced by tramadol, but not endothelium-denuded rings. Conclusion: In the rabbit aorta, vascular relaxation induced by tramadol is due to both nitric oxide production from endothelium and a direct effect on smooth muscle. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SHANGHAI INST MATERIA MEDICA | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | tramadol | en_US |
dc.subject | thoracic aorta | en_US |
dc.subject | endothelium | en_US |
dc.subject | vasodilation | en_US |
dc.title | High-concentration tramadol-induced vasodilation in rabbit aorta is mediated by both endothelium-dependent and -independent mechanisms | en_US |
dc.type | article | en_US |
dc.relation.journal | ACTA PHARMACOLOGICA SINICA | en_US |
dc.contributor.department | Cumhuriyet Univ, Fac Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Fac Med, Dept Anaesthesiol, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | 389 | en_US |
dc.identifier.startpage | 385 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |