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dc.contributor.authorKoyuncu, A
dc.contributor.authorYildirim, S
dc.contributor.authorAydin, C
dc.contributor.authorBagcivan, I
dc.contributor.authorSarac, B
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:23:34Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:23:34Z
dc.date.issued2003
dc.identifier.issn0944-1174
dc.identifier.urihttps://dx.doi.org/10.1007/s00535-002-1082-7
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11394
dc.descriptionWOS: 000183185500006en_US
dc.descriptionPubMed ID: 12768388en_US
dc.description.abstractBackground The internal anal sphincter is a specialized continuation of the circular smooth muscle layer of the rectum. It has been found that internal anal sphincter tonus is significantly increased in the majority of patients with anal fissure. Adrenomedullin has a relaxant effect on smooth muscle in different kinds of tissue. In this in vitro study, we aimed to investigate whether adrenomedullin had a relaxant effect on isolated rabbit internal anal sphincter, and the possible involvement of nitric oxide, prostaglandins, and K+ channels. Methods. Internal anal sphincter smooth muscle strips obtained from New Zealand rabbits were studied in vitro. The effects of adrenomedullin were investigated in isolated strips of rabbit internal anal sphincter smooth muscle precontracted with carbachol alone, and in the presence of indomethacin (a cyclooxygenase inhibitor), N-omega-nitro-L-arginine methyl ester (L-NAME; a nitric oxide synthetase inhibitor), and K+ channel blockers. Results. Adrenomedullin caused relaxation of the isolated precontracted rabbit internal anal sphincter strips in a concentration-dependent manner. The response of the internal anal sphincter was not affected by L-NAME, indomethacin, and the K+ channel blockers. Conclusions. This relaxant effect of adrenomedullin might lead to novel clinical applications of adrenomedullin for anorectal disorders with increased internal anal sphincter tonus, such as anal fissure.en_US
dc.language.isoengen_US
dc.publisherSPRINGER-VERLAG TOKYOen_US
dc.relation.isversionof10.1007/s00535-002-1082-7en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadrenomedullinen_US
dc.subjectinternal anal sphincteren_US
dc.subjectanal fissureen_US
dc.titleRelaxation effects of adrenomedullin in carbachol-precontracted rabbit internal anal sphincteren_US
dc.typearticleen_US
dc.relation.journalJOURNAL OF GASTROENTEROLOGYen_US
dc.contributor.departmentCumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Gen Surg, TR-58140 Sivas, Turkeyen_US
dc.identifier.volume38en_US
dc.identifier.issue5en_US
dc.identifier.endpage464en_US
dc.identifier.startpage460en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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