dc.contributor.author | Inan, M | |
dc.contributor.author | Koyuncu, A | |
dc.contributor.author | Aydin, C | |
dc.contributor.author | Turan, M | |
dc.contributor.author | Gokgoz, S | |
dc.contributor.author | Sen, M | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:23:55Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:23:55Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 0941-1291 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s005950300004 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11462 | |
dc.description | WOS: 000181248500005 | en_US |
dc.description | PubMed ID: 12560903 | en_US |
dc.description.abstract | Purpose. The levels of thyroid hormones decrease in septic, critically ill, and major trauma patients who show a bad prognosis. The aim of this study was to investigate the effects of thyroid hormone supplementation on the sepsis criteria and mortality in an experimental sepsis model. Methods. Forty-eight Wistar-Albino rats were divided into four experimental groups. A cecum ligation and puncture was used as a sepsis model. Group I: sham; group II: a cecum ligation and puncture (control); group III: a cecum ligation and puncture +T3 (0.4 mug/100g body weight/day) intraperitoneally; group IV: a cecum ligation and puncture +T4 (1500ng/100g body weight/day) intramuscularly. The PCO2, leukocyte count, peritoneal bacterial content, neutropenia, and mortality rates were assessed in all groups. Results. The PCO2 levels decreased only in the control group (P < 0.05). The leukocyte counts were lower in the therapy groups (P < 0.05). The rate of neutropenia was seen much more in the control group (P < 0.05). The peritoneal bacteria content decreased in the therapy groups (P < 0.05). The mortality rate significantly decreased in the thyroid hormone-treated animals (P < 0.05). Conclusions. Thyroid hormone supplementation in septic rats had a beneficial effect on the sepsis criteria and also resulted in a lower rate of mortality. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER-VERLAG | en_US |
dc.relation.isversionof | 10.1007/s005950300004 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | thyroid hormone | en_US |
dc.subject | sepsis | en_US |
dc.subject | euthyroid sick syndrome | en_US |
dc.title | Thyroid hormone supplementation in sepsis: An experimental study | en_US |
dc.type | article | en_US |
dc.relation.journal | SURGERY TODAY | en_US |
dc.contributor.department | Cumhuriyet Univ, Sch Med, Dept Gen Surg, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 33 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 29 | en_US |
dc.identifier.startpage | 24 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |