dc.contributor.author | Kaya, T | |
dc.contributor.author | Guvenal, T | |
dc.contributor.author | Karadas, B | |
dc.contributor.author | Cetin, A | |
dc.contributor.author | Soydan, AS | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:23:59Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:23:59Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0301-2115 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11474 | |
dc.description | WOS: 000179086200002 | en_US |
dc.description | PubMed ID: 12381471 | en_US |
dc.description.abstract | Objective: The effects of 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB), anthracene-9-carboxylate (9-AC) (chloride channel blockers) and zaprinast (an inhibitor of phosphodiesterase-5) on endothelin-1 (ET-1) induced contractions of pregnant rat myometrium were investigated in vitro. Methods: Isolated myometrial strips were obtained from pregnant rats, and the strips were mounted in organ baths for recording of isometric tension (n = 8). The effects of 10(-7) to 10(-4) M NPPB, 10(-7) to 10(-4) M 9-AC, and 10(-7) to 10(-4) M zaprinast on 10(-8) M ET-1-induced contractions of pregnant rat myometrial smooth muscle were recorded. Results: NPPB and 9-AC increased the amplitude of ET-1-induced myometrial contractions, while decreasing the frequency, in a concentration-dependent manner. The amplitude of myometrial contractions were significantly increased by NPPB and 9-AC beginning from the concentration of 10(-6) M. The frequency of myometrial contractions were significantly decreased by NPPB and 9-AC beginning from the concentration of 10(-6) M. Zaprinast inhibited the amplitude and frequency of ET-1-induced myometrial contractions in a concentration-dependent manner. Zaprinast-induced decreases in amplitude and frequency of myometrial contractions reached statistical significance beginning from the concentrations of 10(-7) M and 10(-5) M, respectively. Conclusion: These data provide evidence that the ET-1-induced contractions of pregnant rat myometrial strips may be modulated by chloride channels. In addition, zaprinast effectively inhibited ET-1-induced contractions in pregnant rat myometrium. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER SCI IRELAND LTD | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | chloride channel blockers | en_US |
dc.subject | phosphodiesterase inhibitor | en_US |
dc.subject | myometrium | en_US |
dc.title | Effects of 5-nitro-2-(3-phenylpropylamino) benzoic acid, anthracene-9-carboxylate, and zaprinast on endothelin-1-induced contractions of pregnant rat myometrium | en_US |
dc.type | article | en_US |
dc.relation.journal | EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY | en_US |
dc.contributor.department | Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | Cetin, Ali -- 0000-0002-5767-7894 | en_US |
dc.identifier.volume | 105 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 119 | en_US |
dc.identifier.startpage | 114 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |