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dc.contributor.authorCandan, F
dc.contributor.authorGultekin, F
dc.contributor.authorCandan, F
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:24:14Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:24:14Z
dc.date.issued2002
dc.identifier.issn0263-6484
dc.identifier.urihttps://dx.doi.org/10.1002/cbf.947
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11516
dc.descriptionWOS: 000175598700004en_US
dc.descriptionPubMed ID: 11979503en_US
dc.description.abstractPeroxidation of the membrane lipid structure of red blood cell leads to haemolysis and anaemia in haemodialysis patients. Dietary constituents of antioxidant vitamins and trace elements may play an important role in protecting against oxidant damage. In this study, the effects of supplementation of vitamin C and zinc on osmotic fragility and lipid peroxidation of erythrocytes were investigated in 34 zinc-deficient haemodialysis patients. Sixteen sex- and age-matched normal volunteers acted as controls. Patients were randomized to receive vitamin C (250 mg day(-1)), zinc (20 mg day(-1)) or a placebo treatment for 3 months. The levels of vitamin C, zinc, malondialdehyde (MDA) and osmotic fragility were measured initially and 3 months after supplementation. Mean serum concentration of vitamin C and zinc increased significantly in the groups at the end of the respective study periods. Supplementation with vitamin C and zinc improved osmotic fragility, and decreased the level of MDA in the groups, but some side-effects (i.e. nausea, vomiting, fever, muscle pain, weakness) were observed during the zinc treatment. The results showed that the supplementation of both treatments decreased osmotic fragilty and MDA in zinc-deficient haemodialysis patients. However, vitamin C treatment was found to be safer than zinc supplementation. Copyright (C) 2001 John Wiley Sons, Ltd.en_US
dc.language.isoengen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.isversionof10.1002/cbf.947en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectzincen_US
dc.subjectvitamin Cen_US
dc.subjectosmotic fragilityen_US
dc.subjectlipid peroxidationen_US
dc.subjecthaemodialysisen_US
dc.titleEffect of vitamin C and zinc on osmotic fragility and lipid peroxidation in zinc-deficient haemodialysis patientsen_US
dc.typearticleen_US
dc.relation.journalCELL BIOCHEMISTRY AND FUNCTIONen_US
dc.contributor.departmentCumhuriyet Univ, Fac Sci & Art, Dept Chem, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Fac Med, Dept Internal Med, TR-58140 Sivas, Turkeyen_US
dc.identifier.volume20en_US
dc.identifier.issue2en_US
dc.identifier.endpage98en_US
dc.identifier.startpage95en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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