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Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries

dc.contributor.authorBerkan, O
dc.contributor.authorSarac, B
dc.contributor.authorSimsek, R
dc.contributor.authorYildirim, S
dc.contributor.authorSarioglu, Y
dc.contributor.authorSafak, C
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:24:15Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:24:15Z
dc.date.issued2002
dc.identifier.issn0223-5234
dc.identifier.urihttps://dx.doi.org/10.1016/S0223-5234(02)01374-0
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11518
dc.descriptionWOS: 000177049200008en_US
dc.descriptionPubMed ID: 12204478en_US
dc.description.abstractIn this study, 1;2 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and. their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was investigated. Pinacidil was used as standard potassium channel openers in this study. Compounds 1-12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order: 11 > pinacidil > 7 > 2 > 8 > 3 > 1 > 4 > 10 > 6 > 9 > 5 > 12. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.en_US
dc.language.isoengen_US
dc.publisherEDITIONS SCIENTIFIQUES MEDICALES ELSEVIERen_US
dc.relation.isversionof10.1016/S0223-5234(02)01374-0en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpotassium channel openersen_US
dc.subjectacridindioneen_US
dc.subjectsynthesisen_US
dc.titleVasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteriesen_US
dc.typearticleen_US
dc.relation.journalEUROPEAN JOURNAL OF MEDICINAL CHEMISTRYen_US
dc.contributor.departmentCumhuriyet Univ, Fac Med, Dept Cardiovasc Surg, Sivas, Turkey -- Cumhuriyet Univ, Fac Med, Dept Pharmacol, Sivas, Turkey -- Univ Hacettepe, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkeyen_US
dc.contributor.authorIDSARIOGLU, YUSUF -- 0000-0002-9227-365Xen_US
dc.identifier.volume37en_US
dc.identifier.issue6en_US
dc.identifier.endpage523en_US
dc.identifier.startpage519en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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