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dc.contributor.authorDeveci, D
dc.contributor.editorTooke, J
dc.contributor.editorShore, A
dc.contributor.editorWhatmore, J
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:24:29Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:24:29Z
dc.date.issued2002
dc.identifier.isbn88-323-2828-3
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11558
dc.description22nd Meeting of the European-Society-for-Microcirculation -- AUG 28-30, 2002 -- EXETER, ENGLANDen_US
dc.descriptionWOS: 000178661600005en_US
dc.description.abstractThe angiogenic response of glycolytic (tibialis anterior, TA) and oxidative (soleus, SOL) muscles of rats to progressive cooling (20 to 5degreesC) for 4 weeks and hypoxia (12%O-2) for 3 weeks was investigated. Consistent areas were investigated in each muscle, with the TA divided into core and cortex regions. Cold exposure increased capillary-to-fibre ratio (C/F) in SOL from 1.97 +/- 0.06 to 2.37 +/- 0.17 (P<0.05, ANOVA), but not in the TA. Capillary density (CD, mm(-2)) and fibre cross sectional area (FCSA, mum(-2)) did not change in either muscle. However, proliferating cell nuclear antigen (PCNA) density increased in SOL (52. +/- 9 vs. 88 +/- 8 mm(-1), P<0.05) and staining co-localised with capillaries also increased from 5.1 +/- 1.6 to 12.9 +/- 1.1 mm-2 (P<0.05) in cold acclimated rats. Hypoxia-induced angiogenesis also occurred in SOL (C/F 2.19 +/- 0.10 vs. 2.64 +/- 0.15, P<0.05), but not in the TA when averaged across the whole muscle. However, in the cortex region of TA angiogenesis was seen (1.45 +/- 0.02 vs. 1.83 +/- 0.07) where FCSA was largest. PCNA density increased in SOL and that co-localised with capillaries also increased in hypoxic rats. These results show that both cold acclimation and hypoxia stimulate angiogenesis in SOL. This may indicate that oxidative capacity and muscle activity levels are important factors for angiogenesis.en_US
dc.description.sponsorshipEuropean Soc Microcirculaten_US
dc.language.isoengen_US
dc.publisherMEDIMOND S R Len_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe effect of cold and hypoxia on angiogenesis in oxidative and glycolytic muscle of ratsen_US
dc.typeconferenceObjecten_US
dc.relation.journal22ND MEETING OF THE EUROPEAN SOCIETY FOR MICROCIRCULATION: MICROCIRCULATION AND VASCULAR BIOLOGYen_US
dc.contributor.departmentCumhuriyet Univ, Dept Physiol, Sch Med, Sivas, Turkeyen_US
dc.identifier.endpage32en_US
dc.identifier.startpage25en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US


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