dc.contributor.author | Kafali, H | |
dc.contributor.author | Kaya, T | |
dc.contributor.author | Gursoy, S | |
dc.contributor.author | Bagcivan, I | |
dc.contributor.author | Karadas, B | |
dc.contributor.author | Sarioglu, Y | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:24:29Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:24:29Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0003-2999 | |
dc.identifier.uri | https://dx.doi.org/10.1097/00000539-200201000-00033 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11559 | |
dc.description | WOS: 000173082800033 | en_US |
dc.description | PubMed ID: 11772823 | en_US |
dc.description.abstract | Volatile anesthetics and K+ channel openers inhibit spontaneous contractions in myometrial smooth muscle. Volatile anesthetics modulate K+ channel activity We investigated the role of two K+ channel blockers on the effect of sevoflurane in pregnant rat myometrium. Term pregnant rat uteri were excised, and cross-sectional myometrial strips were mounted for isometric force recording. Sevoflurane inhibited the amplitude and frequency of spontaneous myometrial contractions in a concentration-dependent manner. The maximal inhibition measured in amplitude and frequency of spontaneous myometrial contractions with sevoflurane (at 3 minimum alveolar anesthetic concentration) was 44.32% and 33.32% of control contractions, respectively. Tetraethylammonium (TEA) and glibenclamide, K+ channel blockers, increased spontaneous myometrial contractions in a concentration-dependent manner. Sevoflurane responses were repeated at concentrations with no effect on spontaneous contractility of TEA, a Ca2+-activated K+ channel blocker, and glibenclamide, an adenosine triphosphate-sensitive K+ channel blocker, in myometrial strips. TEA (3.10(-4) M) caused a significant reduction in sevoflurane-induced inhibitor responses, but glibenclamide (10(-6) M) did not. Sevoflurane-induced maximal inhibition (at 3 minimum alveolar anesthetic concentration) on amplitude and frequency of spontaneous myometrial contractions in the presence of TEA (3.10(-4) M) was 31.85% and 22.33% of control contractions, respectively (P < 0,05). These results suggest that the in vitro application of sevoflurane inhibited the amplitude and frequency of spontaneous myometrial contractions in pregnant rats in a concentration-dependent manner. Such inhibition was reduced by TEA. The inhibition of myometrial smooth muscle induced by sevoflurane seems to be mediated, at least in part, via activation of Ca2+-activated K+ channels, because inhibition was reduced by TEA. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.relation.isversionof | 10.1097/00000539-200201000-00033 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.title | The role of K+ channels on the inhibitor effect of sevoflurane in pregnant rat myometrium | en_US |
dc.type | article | en_US |
dc.relation.journal | ANESTHESIA AND ANALGESIA | en_US |
dc.contributor.department | Cumhuriyet Univ, Sch Med, Dept Anesthesiol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | SARIOGLU, YUSUF -- 0000-0002-9227-365X | en_US |
dc.identifier.volume | 94 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 178 | en_US |
dc.identifier.startpage | 174 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |