dc.contributor.author | Arici, MK | |
dc.contributor.author | Sayici, M | |
dc.contributor.author | Toker, MI | |
dc.contributor.author | Erdogan, H | |
dc.contributor.author | Topalkara, A | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:24:32Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:24:32Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0950-222X | |
dc.identifier.issn | 1476-5454 | |
dc.identifier.uri | https://dx.doi.org/10.1038/sj/EYE/6700035 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11565 | |
dc.description | WOS: 000174748600008 | en_US |
dc.description | PubMed ID: 11913886 | en_US |
dc.description.abstract | Purpose To evaluate the additive ocular hypotensive effect of the combination of brimonidine and timolol on intraocular pressure (IOP) reduction in patients with glaucoma. Methods This was a prospective, randomized, double-masked, crossover study in 20 patients with primary open angle glaucoma (POAG) on therapy receiving timolol maleate 0.5% twice daily, with IOP greater than or equal to 22 mmHg in one eye. The treatment period was 3 weeks and during this period timolol + brimonidine or timolol + placebo were applied topically twice daily and IOP, blood pressure, heart rate and pupil size were measured. Results Combined therapy (timolol + brimonidine) had clinically significant IOP-lowering effect during the treatment period (P<0.01). The mean diurnal IOP was significantly reduced by an average of 5.1-5.9 mmHg (21.2-24.5%) compared with baseline value. The timolol + placebo combination had no clinically significant IOP-lowering effect (P>0.05). No clinically significant side effects were observed during the treatment of both groups. Conclusions This study showed that the combination of topically applied brimonidine and timolol cause a marked and sustained IOP reduction. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.relation.isversionof | 10.1038/sj/EYE/6700035 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | glaucoma | en_US |
dc.subject | timolol | en_US |
dc.subject | brimonidine | en_US |
dc.title | A short term study of the additive effect of timolol and brimonidine on intraocular pressure | en_US |
dc.type | article | en_US |
dc.relation.journal | EYE | en_US |
dc.contributor.department | Cumhuriyet Univ, Sch Med, Dept Ophthalmol, Sivas, Turkey | en_US |
dc.contributor.authorID | arici, mustafa kemal -- 0000-0002-6350-9723 | en_US |
dc.identifier.volume | 16 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 43 | en_US |
dc.identifier.startpage | 39 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |