dc.contributor.author | Hosoglu, S | |
dc.contributor.author | Geyik, MF | |
dc.contributor.author | Balik, I | |
dc.contributor.author | Aygen, B | |
dc.contributor.author | Erol, S | |
dc.contributor.author | Aygencel, TG | |
dc.contributor.author | Mert, A | |
dc.contributor.author | Saltoglu, N | |
dc.contributor.author | Dokmetas, I | |
dc.contributor.author | Felek, S | |
dc.contributor.author | Sunbul, M | |
dc.contributor.author | Irmak, H | |
dc.contributor.author | Aydin, K | |
dc.contributor.author | Kokoglu, OF | |
dc.contributor.author | Ucmak, H | |
dc.contributor.author | Altindis, M | |
dc.contributor.author | Loeb, M | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:24:33Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:24:33Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 1027-3719 | |
dc.identifier.issn | 1815-7920 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11569 | |
dc.description | WOS: 000174776100010 | en_US |
dc.description | PubMed ID: 11931403 | en_US |
dc.description.abstract | OBJECTIVE: To assess predictors of mortality and neurological sequelae in patients with tuberculous meningitis (TBM). METHODS: Patients with TBM treated at 12 university hospitals in Turkey between 1985 and 1997 were evaluated using a standardised protocol applied retrospectively. Variables associated with hospital mortality as well as with the presence of neurological sequelae at 6 months were determined using logistic regression models. RESULTS: Four hundred and thirty-four patients between the ages of 13 and 83 years (mean 33 years) were evaluated. Sixty-eight per cent of these patients presented with Medical Research Council Stage H or III. One hundred and one patients (23.3%) died and 67 (27%) of evaluable survivors had neurological sequelae. In multivariable analysis, convulsion (OR 3.3, 95%CI 1.2-9.0, P = 0.02), comatose mental status (OR 6.0, 95%CI 3.6-10.2, P = 0.01), and delayed or interrupted treatment (OR 5.1, 95%CI 2.4-11.2, P = 0.01) were shown to be predictors for mortality. The presence of extra-meningeal tuberculosis (OR 2.1, 95%CI 1.1-4.2, P = 0.035), cranial nerve palsy (OR 2.6, 95%CI 1.4-4.2, P = 0.01), hemiparesia/focal weakness (OR 9.3, 95%CI 3.8-22.6, P = 0.01), hemiplegia/multiple neurological deficit (OR 7.1, 95%CI 2.14-23.38, P = 0.01) and drowsiness (OR 4.2, 95%CI 2.04-8.82, P = 0.01) were independent predictors of neurological sequelae at 6 months following hospital discharge. CONCLUSION: The results of this study emphasise the importance of prompt and uninterrupted anti-tuberculosis therapy for tuberculous meningitis. The presence of seizures or coma on admission to hospital are important predictors for mortality, while the presence of focal neurological signs is a predictor for persistent neurological sequelae in survivors. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D) | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | tuberculous meningitis | en_US |
dc.subject | outcome | en_US |
dc.subject | independent factors | en_US |
dc.title | Predictors of outcome in patients with tuberculous meningitis | en_US |
dc.type | article | en_US |
dc.relation.journal | INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | en_US |
dc.contributor.department | Dicle Univ, Tip Fak Enfeksiyon Hastaliklari Anabilim Dali, Dept Clin Microbiol, TR-21280 Diyarbakir, Turkey -- Dicle Univ, Tip Fak Enfeksiyon Hastaliklart Anabilim Dali, Dept Infect Dis, TR-21280 Diyarbakir, Turkey -- Ankara Univ Hosp, Ankara, Turkey -- Erciyes Univ Hosp, Kayseri, Turkey -- Ataturk Univ Hosp, Erzurum, Turkey -- Hacettepe Univ Hosp, Ankara, Turkey -- Cerrahpasa Hosp, Istanbul, Turkey -- Cukurova Univ Hosp, Adana, Turkey -- Cumhuriyet Univ Hosp, Sivas, Turkey -- Firat Univ Hosp, Elazig, Turkey -- Ondokuz Mayis Univ Hosp, Samsun, Turkey -- Yuzuncu Yil Univ Hosp, Van, Turkey -- Karadeniz Tech Univ Hosp, Trabzon, Turkey -- Kocatepe Univ Hosp, Afyon, Turkey -- Hamilton Civ Hosp, Hamilton, ON, Canada -- McMaster Univ, Hamilton, ON, Canada | en_US |
dc.contributor.authorID | Geyik, Mehmet Faruk -- 0000-0002-0906-0902; Altindis, Mustafa -- 0000-0003-0411-9669; dokmetas, ilyas -- 0000-0003-3523-3923 | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.endpage | 70 | en_US |
dc.identifier.startpage | 64 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |