dc.contributor.author | Ceran, C | |
dc.contributor.author | Sonmez, K | |
dc.contributor.author | Turkyilmaz, Z | |
dc.contributor.author | Demirogullari, B | |
dc.contributor.author | Dursun, A | |
dc.contributor.author | Duzgun, E | |
dc.contributor.author | Basaklar, AC | |
dc.contributor.author | Kale, N | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:24:42Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:24:42Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 0022-3468 | |
dc.identifier.uri | https://dx.doi.org/10.1053/jpsu.2001.28816 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11592 | |
dc.description | WOS: 000172574700008 | en_US |
dc.description | PubMed ID: 11733902 | en_US |
dc.description.abstract | Purpose: The aim of this study was to determine the effects of bilirubin in experimental small intestinal ischemia/reperfusion (I/R) injury in rats. Methods, Thirty rats were divided into 5 groups (n = 6). In group S, saline and in group B, bilirubin, 20 mg/kg were infused via the jugular vein without an additional procedure. In groups S-IR, saline, B-1-IR and B-2-IR, 10 and 20 mg/kg/h of bilirubin were infused for 2 hours, respectively. In these groups, an I/R procedure was done after infusions by occluding the superior mesenteric artery for 45 minutes followed by 1 hour of reperfusion. After reperfusion, the small intestines were resected for histopathologic and malondialdehyde (MDA) assessments. Mucosal lesions were scored between 0 and 5. Malondialdehyde levels and histopathologic grades were analyzed statistically. Results: Mucosal injury was severe in S-IR (grade 4 to 5), mild in B-1-IR (grade 0 to 3) and none in B-2-IR group (grade 0). Grades of group S-IR were higher than those of B-1-IR and B-2-IR statistically (P < .05). Tissue MDA levels of the S-IR group were significantly higher than those of B-1-IR and B-2-IR groups (U = 36, P < .05). Bilirubin levels correlated inversely with MDA levels (r = -0.94). Conclusions: Bilirubin effectively prevents intestinal I/R injury in rat. This observation is consistent with the hypotheses regarding bilirubin as an antioxidant, having a role in the body defense. Copyright (C) 2001 by WB. Saunders Company. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | W B SAUNDERS CO | en_US |
dc.relation.isversionof | 10.1053/jpsu.2001.28816 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | bilirubin | en_US |
dc.subject | ischemia/reperfusion injury | en_US |
dc.subject | intestine | en_US |
dc.title | Effect of bilirubin in ischemia/reperfusion injury on rat small intestine | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF PEDIATRIC SURGERY | en_US |
dc.contributor.department | Gazi Univ, Sch Med, Dept Pediat Surg, Ankara, Turkey | en_US |
dc.identifier.volume | 36 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.endpage | 1767 | en_US |
dc.identifier.startpage | 1764 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |