dc.contributor.author | Guvenal, T | |
dc.contributor.author | Cetin, A | |
dc.contributor.author | Ozdemir, H | |
dc.contributor.author | Yanar, O | |
dc.contributor.author | Kaya, T | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:24:49Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:24:49Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 0268-1161 | |
dc.identifier.uri | https://dx.doi.org/10.1093/humrep/16.8.1732 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11611 | |
dc.description | WOS: 000170441100036 | en_US |
dc.description | PubMed ID: 11473974 | en_US |
dc.description.abstract | BACKGROUND: Pelvic surgery is one of the main causes of intraperitoneal (i.p.) adhesions that create various medical problems including pelvic pain, bowel obstructions and female infertility. A rat model was used to investigate the efficacy of nimesulide, a selective cyclooxygenase-2 inhibitor, in the prevention of adhesion formation. METHODS: Fifty Wistar-Albino rats underwent bilateral uterine horn injury with a unipolar cautery. Study groups were as follows: (i) control group, no adjuvant therapy; (ii) i.p. Ringer's lactate group, 2 ml Ringer's lactate solution was instilled i.p.; (iii) i.p. Ringer's lactate plus nimesulide group, I ml Ringer's lactate plus 1 ml nimesulide (0.5 mg/ml) were given i.p.; (iv) intramuscular (i.m.) nimesulide group, 1 ml i.m. nimesulide (0.5 mg/ml) was given preoperatively for 5 days; and (v) i.p. nimesulide group, 1 ml nimesulide (0.5 mg/ml) was instilled i.p. At the end of the study all animals were killed, and a standard adhesion scoring system was applied by a blinded examiner. RESULTS: The mean adhesion extent in study groups was as follows: 1.33 +/- 0.76 in control group, 1.40 +/- 0.90 in i.p. Ringer's lactate group, 0.75 +/- 0.70 in i.p. Ringer's lactate plus nimesulide group, 0.25 +/- 0.44 in i.m. nimesulide group and 0.31 +/- 0.70 in i.p. nimesulide group. The mean +/- SD adhesion severities of control, i.p. Ringer's lactate, i.p. Ringer's lactate plus nimesulide, i.m. nimesulide, and i.p. nimesulide groups were 0.58 +/- 0.35, 0.30 +/- 0.41, 0.27 +/- 0.3, 0.12 +/- 0.28 and 0.15 +/- 0.35 respectively. The lowest adhesions were found in the groups treated with nimesulide i.m. and nimesulide i.p. (P < 0.05). CONCLUSIONS: This study showed that preoperative i.m. or postoperative i.p. administration of nimesulide to the site of injury reduced the formation of postoperative adhesions in a rat uterine horn model. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | OXFORD UNIV PRESS | en_US |
dc.relation.isversionof | 10.1093/humrep/16.8.1732 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | adhesion | en_US |
dc.subject | nimesulide | en_US |
dc.subject | postoperative | en_US |
dc.subject | rat | en_US |
dc.subject | surgery | en_US |
dc.title | Prevention of postoperative adhesion formation in rat uterine horn model by nimesulide: a selective COX-2 inhibitor | en_US |
dc.type | article | en_US |
dc.relation.journal | HUMAN REPRODUCTION | en_US |
dc.contributor.department | Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | Cetin, Ali -- 0000-0002-5767-7894 | en_US |
dc.identifier.volume | 16 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.endpage | 1735 | en_US |
dc.identifier.startpage | 1732 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |