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dc.contributor.authorGuvenal, T
dc.contributor.authorCetin, A
dc.contributor.authorOzdemir, H
dc.contributor.authorYanar, O
dc.contributor.authorKaya, T
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:24:49Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:24:49Z
dc.date.issued2001
dc.identifier.issn0268-1161
dc.identifier.urihttps://dx.doi.org/10.1093/humrep/16.8.1732
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11611
dc.descriptionWOS: 000170441100036en_US
dc.descriptionPubMed ID: 11473974en_US
dc.description.abstractBACKGROUND: Pelvic surgery is one of the main causes of intraperitoneal (i.p.) adhesions that create various medical problems including pelvic pain, bowel obstructions and female infertility. A rat model was used to investigate the efficacy of nimesulide, a selective cyclooxygenase-2 inhibitor, in the prevention of adhesion formation. METHODS: Fifty Wistar-Albino rats underwent bilateral uterine horn injury with a unipolar cautery. Study groups were as follows: (i) control group, no adjuvant therapy; (ii) i.p. Ringer's lactate group, 2 ml Ringer's lactate solution was instilled i.p.; (iii) i.p. Ringer's lactate plus nimesulide group, I ml Ringer's lactate plus 1 ml nimesulide (0.5 mg/ml) were given i.p.; (iv) intramuscular (i.m.) nimesulide group, 1 ml i.m. nimesulide (0.5 mg/ml) was given preoperatively for 5 days; and (v) i.p. nimesulide group, 1 ml nimesulide (0.5 mg/ml) was instilled i.p. At the end of the study all animals were killed, and a standard adhesion scoring system was applied by a blinded examiner. RESULTS: The mean adhesion extent in study groups was as follows: 1.33 +/- 0.76 in control group, 1.40 +/- 0.90 in i.p. Ringer's lactate group, 0.75 +/- 0.70 in i.p. Ringer's lactate plus nimesulide group, 0.25 +/- 0.44 in i.m. nimesulide group and 0.31 +/- 0.70 in i.p. nimesulide group. The mean +/- SD adhesion severities of control, i.p. Ringer's lactate, i.p. Ringer's lactate plus nimesulide, i.m. nimesulide, and i.p. nimesulide groups were 0.58 +/- 0.35, 0.30 +/- 0.41, 0.27 +/- 0.3, 0.12 +/- 0.28 and 0.15 +/- 0.35 respectively. The lowest adhesions were found in the groups treated with nimesulide i.m. and nimesulide i.p. (P < 0.05). CONCLUSIONS: This study showed that preoperative i.m. or postoperative i.p. administration of nimesulide to the site of injury reduced the formation of postoperative adhesions in a rat uterine horn model.en_US
dc.language.isoengen_US
dc.publisherOXFORD UNIV PRESSen_US
dc.relation.isversionof10.1093/humrep/16.8.1732en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectadhesionen_US
dc.subjectnimesulideen_US
dc.subjectpostoperativeen_US
dc.subjectraten_US
dc.subjectsurgeryen_US
dc.titlePrevention of postoperative adhesion formation in rat uterine horn model by nimesulide: a selective COX-2 inhibitoren_US
dc.typearticleen_US
dc.relation.journalHUMAN REPRODUCTIONen_US
dc.contributor.departmentCumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDCetin, Ali -- 0000-0002-5767-7894en_US
dc.identifier.volume16en_US
dc.identifier.issue8en_US
dc.identifier.endpage1735en_US
dc.identifier.startpage1732en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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