dc.contributor.author | Yarar, Y | |
dc.contributor.author | Cetin, A | |
dc.contributor.author | Kaya, T | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:24:50Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:24:50Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 1071-5576 | |
dc.identifier.uri | https://dx.doi.org/10.1016/S1071-5576(01)00113-7 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11614 | |
dc.description | WOS: 000170739100004 | en_US |
dc.description | PubMed ID: 11525895 | en_US |
dc.description.abstract | OBJECTIVE: We compared in vitro relaxant effect of chloride channel modulators, such as 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) and anthracene-9-carboxylate (9-AC), and beta (2)-adrenergic agonists, such as ritodrine, in pregnant rat myometrium. METHODS: Isolated myometrial strips were obtained from eight pregnant rats, and the strips were mounted in organ baths for recording isometric tension. The effects of 10(-8)-10(-4) M ritodrine, 10(-6)-3 x 10(-4) M NPPB, and 10(-6) -10(-3) M 9-AC on spontaneous contractions were recorded. RESULTS: Ritodrine (10(-8)-10(-5) M) completely inhibited the amplitude and frequency of spontaneous contractions in myometrial strips isolated from pregnant rats in a concentration-dependent manner, but the relaxant effect of ritodrine at 10(-4) M concentration resulted in tachyphylaxis. The chloride channel blocker NPPB (10(-6)-3 x 10(-4) M) and the chloride transport inhibitor 9-AC (10(-5)-10(-3) M) decreased the amplitude of spontaneous myometrial contractions in a concentration-dependent manner; the maximum inhibition produced by the highest tested concentration of each drug nus 43.8% and 42.1% of the original degree of spontaneous contractions, respectively. The freqnency of myometrial contractions was significantly inhibited by NPPB and 9-AC beginning with the concentration of 10(-4) M. CONCLUSION: NPPB and 9-AC appear to be effective relaxants of pregnant rat myometrium. These effects of NPPB and 9-AC might be therapeutically advantageous in clinical management of preterm labor. (J Soc Gynecol Investiq 2001;8:206-9) Copyright (C) 2001 by the Society for Gynecologic Investigation. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.relation.isversionof | 10.1016/S1071-5576(01)00113-7 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | NPPB | en_US |
dc.subject | 9-AC | en_US |
dc.subject | ritodrine | en_US |
dc.subject | myometrium | en_US |
dc.subject | rat | en_US |
dc.title | Chloride channel blockers 5-nitro-2-(3-phenylpropylamino) benzoic acid and anthracene-9-carboxylic acid inhibit contractions of pregnant rat myometrium in vitro | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION | en_US |
dc.contributor.department | Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey | en_US |
dc.contributor.authorID | Cetin, Ali -- 0000-0002-5767-7894 | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 209 | en_US |
dc.identifier.startpage | 206 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |