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dc.contributor.authorKoyluoglu, G
dc.contributor.authorBakici, MZ
dc.contributor.authorElagoz, S
dc.contributor.authorArpacik, M
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:24:56Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:24:56Z
dc.date.issued2001
dc.identifier.issn1591-8890
dc.identifier.urihttps://dx.doi.org/10.1007/PL00012238
dc.identifier.urihttps://hdl.handle.net/20.500.12418/11627
dc.descriptionWOS: 000175302100009en_US
dc.descriptionPubMed ID: 11467403en_US
dc.description.abstractBacterial translocation is thought to be responsible for infectious complications after hemorrhagic shock. The aim of this study was to investigate the effects of pentoxifylline treatment on bacterial translocation in animals subjected to hemorrhagic shock. Thirty-one Wistar albino rats (280360 g) were divided into three groups: sham (n=10), shock (n=11), and shock-pentoxifylline (n=10). Blood was not withdrawn from sham rats. Shock rats were subjected to 30 min of shock followed by reinfusion of shed blood. Shock/pentoxifylline rats received pentoxifylline after reinfusion of shed blood. After hemorrhage and reinfusion (24 h), the mesenteric lymph nodes, liver, spleen, and blood samples were evaluated using quantitative microbiological techniques, and the numbers of colony-forming units were compared between groups. Cecum was removed to evaluate the bacterial population. Ileum and cecum were examined histologically. The incidence of bacterial translocation was higher in the shocked rats (63%) than in the sham shock rats (10%). Pentoxifylline reduced the incidence of shock-induced bacterial translocation to 0%. Cecal bacterial levels were significantly higher in the shock rats than in the sham and shock/pentoxifylline rats. The histological damage caused by hemorrhagic shock was prevented by pentoxifylline treatment. In conclusion, the hemorrhagic shock triggered translocation of bacteria to the mesenteric lymph nodes, spleen, liver, and blood of rats. Pentoxifylline treatment just after shed blood transfusion significantly attenuated this phenomenon.en_US
dc.language.isoengen_US
dc.publisherSPRINGER-VERLAGen_US
dc.relation.isversionof10.1007/PL00012238en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbacterial translocationen_US
dc.subjecthemorrhagic shocken_US
dc.subjectpentoxifyllineen_US
dc.subjectanimal modelen_US
dc.titleThe effects of pentoxifylline treatment on bacterial translocation after hemorrhagic shock in ratsen_US
dc.typearticleen_US
dc.relation.journalCLINICAL AND EXPERIMENTAL MEDICINEen_US
dc.contributor.departmentCumhuriyet Univ, Fac Med, Dept Pediat Surg, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Fac Med, Dept Microbiol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Fac Med, Dept Pathol, TR-58140 Sivas, Turkeyen_US
dc.contributor.authorIDKoyluoglu, Gokhan -- 0000-0002-1140-169Xen_US
dc.identifier.volume1en_US
dc.identifier.issue1en_US
dc.identifier.endpage66en_US
dc.identifier.startpage61en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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